Risk Modeling — Publications

Ethnic Mixture and Body Mass Index as Modifiers of Breast Cancer Risk among Native Hawaiian Women: Insights from the Multiethnic Cohort

Valdez D, Abe JV, Bohmann P, Bogumil D, Wilkens LR, Marchand LL, Haiman CA, Shepherd JA, Maskarinec G

Cancer Epidemiology Biomarkers & Prevention, 35, 597-603 (2026)

Visual demonstration of weight loss and health risk improvement with a dual GIP and GLP-1 receptor agonist

Ramirez S, Yang R, Habibovic M, Kennedy S, Bennett JP, Shepherd JA, Thomas DM, Heymsfield SB

International Journal of Obesity, 49, 2005-2010 (2025)

High dietary total energy intake and energy density are associated with girls’ breast density during puberty

Carrasco C, Garmendia ML, Martínez-Arroyo A, Shepherd J, Pereira A

European Journal of Nutrition, 64, 245 (2025)

The gSOS polygenic score is associated with bone density and fracture risk in childhood

Mitchell JA, Bradfield JP, McCormack SE, Chesi A, Kalkwarf HJ, Lappe JM, Oberfield SE, Duren DL, Shepherd J, Hankenson KD, Kelly A, Håkonarson H, Grant SF, Zemel BS

Journal of Bone and Mineral Research, 41, 15-24 (2025)

Prediction of mammographic breast density based on clinical breast ultrasound images using deep learning: a retrospective analysis

Bunnell A, Valdez D, Wolfgruber T, Quon BK, Hung K, Hernandez BY, Seto TB, Killeen J, Miyoshi M, Sadowski P, Shepherd J

The Lancet Regional Health - Americas, 46, 101096 (2025)

Prediction of future visceral adiposity and application to cancer research: The Multiethnic Cohort Study

Wilkens LR, Castelfranco AM, Monroe KR, Kristal BS, Cheng I, Maskarinec G, Hullar MA, Lampe JW, Shepherd J, Franke AA, Ernst T, Marchand LL, Lim U

PLoS ONE, 19, e0306606 (2024)

The Associations between Intakes of One-Carbon Metabolism–Related Vitamins and Breast Density among Young Women

Han E, Horn LV, Snetselaar L, Shepherd J, Park YJ, Kim H, Jung S, Dorgan JF

Cancer Epidemiology Biomarkers & Prevention, 33, 567-575 (2024)

The Prospective Association between Early Life Growth and Breast Density in Young Adult Women

Lloyd R, Pirikahu S, Walter EJ, Cadby G, Warrington NM, Perera D, Hickey M, Saunders C, Hackmann MJ, Sampson DD, Shepherd J, Lilge L, Stone J

Cancers, 16, 2418 (2024)

Time‐specific impact of trace metals on breast density of adolescent girls in Santiago, Chile

Kim CE, Pereira A, Binder AM, Amarasiriwardena C, Shepherd J, Corvalán C, Michels KB

International Journal of Cancer, 155, 627-636 (2024)

The DIRAC framework: Geometric structure underlies roles of and in combining classifiers

Sniatynski MJ, Shepherd J, Wilkens LR, Hsu DF, Kristal BS

Patterns, 5, 100924 (2024)

Breast composition during and after puberty: the Chilean Growth and Obesity Cohort Study

Pereira A, Garmendia ML, Leiva V, Corvalán C, Michels KB, Shepherd J

Breast Cancer Research, 26, 45 (2024)

The distribution of breast density in women aged 18 years and older

Perera D, Pirikahu S, Walter J, Cadby G, Darcey E, Lloyd R, Hickey M, Saunders C, Hackmann MJ, Sampson DD, Shepherd J, Lilge L, Stone J

Breast Cancer Research and Treatment, 205, 521-531 (2024)

Untargeted serum metabolomic profiles and breast density in young women

Jung S, Silva S, Dallal CM, LeBlanc ES, Paris K, Shepherd J, Snetselaar L, Horn LV, Zhang Y, Dorgan JF

Cancer Causes & Control, 35, 323-334 (2023)

Time-specific impact of mono-benzyl phthalate (MBzP) and perfluorooctanoic acid (PFOA) on breast density of a Chilean adolescent Cohort

Kim CE, Binder AM, Corvalán C, Pereira A, Shepherd J, Calafat AM, Botelho JC, Hampton JM, Trentham‐Dietz A, Michels KB

Environment International, 181, 108241 (2023)

Habitual Phytoestrogen Intake Is Associated with Breast Composition in Girls at 2 Years after Menarche Onset

Lesser C, Mericq V, Reyes M, Garmendia ML, Shepherd JA, Michels KB, Corvalán C, Pereira A

Cancer Epidemiology Biomarkers & Prevention, 31, 1334-1340 (2022)

Prognostic utility of self‐reported sarcopenia (SARC‐F) in the Multiethnic Cohort

Wu AH, Setiawan VW, Lim U, Tseng C, White KK, Shepherd J, Lenz HJ, Cheng I, Stram DO, Haiman CA, Wilkens LR, Marchand LL

Journal of Cachexia Sarcopenia and Muscle, 13, 987-1002 (2022)

Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls

Yoon L, Binder AM, Pereira A, Calafat AM, Shepherd J, Corvalán C, Michels KB

Environment International, 170, 107586 (2022)

Deep learning predicts all-cause mortality from longitudinal total-body DXA imaging

Glaser Y, Shepherd J, Leong LT, Wolfgruber T, Lui L, Sadowski P, Cummings SR

Communications Medicine, 2, 102 (2022)

A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women

Kehm RD, Walter EJ, Pereira A, White M, Oskar S, Michels KB, Shepherd J, Lilge L, Terry MB

Scientific Reports, 12, 13547 (2022)

Three‐dimensional optical body shape and features improve prediction of metabolic disease risk in a diverse sample of adults

Bennett JP, Liu YE, Quon BK, Kelly NN, Leong LT, Wong MC, Kennedy S, Chow DC, Garber AK, Weiss EJ, Heymsfield SB, Shepherd J

Obesity, 30, 1589-1598 (2022)

Biomarker-based visceral adiposity score and incident type 2 diabetes in the multiethnic cohort

Maskarinec G, Raquinio PA, Setiawan VW, Ernst T, Franke AA, Buchthal SD, Shepherd J, Wilkens LR, Lim U, Marchand LL

Annals of Epidemiology, 63, 29-34 (2021)

Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk

Rustagi AS, Scott CG, Winham SJ, Brandt KR, Norman AD, Jensen MR, Shepherd J, Hruska CB, Heine J, Pankratz VS, Kerlikowske K, Vachon CM

JNCI Cancer Spectrum, 5, (2021)

Ranks underlie outcome of combining classifiers: Quantitative roles for and

Sniatynski MJ, Shepherd J, Ernst T, Wilkens LR, Hsu DF, Kristal BS

Patterns, 3, 100415 (2021)

Dual-energy three-compartment breast imaging for compositional biomarkers to improve detection of malignant lesions

Leong LT, Malkov S, Drukker K, Niell BL, Sadowski P, Wolfgruber T, Greenwood H, Joe BN, Kerlikowske K, Giger ML, Shepherd J

Communications Medicine, 1, 29 (2021)

The potential of using artificial intelligence to improve skin cancer diagnoses in Hawai‘i’s multiethnic population

Willingham ML, Spencer SY, Lum C, Sanchez JMN, Burnett T, Shepherd J, Cassel K

Melanoma Research, 31, 504-514 (2021)

Mammographic Variation Measures, Breast Density, and Breast Cancer Risk

Heine J, Fowler E, Scott CG, Jensen MR, Shepherd J, Hruska CB, Winham SJ, Brandt KR, Wu F, Norman AD, Pankratz VS, Miglioretti DL, Kerlikowske K, Vachon CM

American Journal of Roentgenology, 217, 326-335 (2021)

Association of mammographic density measures and breast cancer “intrinsic” molecular subtypes

Kleinstern G, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Bertrand KA, …, Shepherd J, et al.

Breast Cancer Research and Treatment, 187, 215-224 (2021)

The Gut Microbiome Is Associated with Circulating Dietary Biomarkers of Fruit and Vegetable Intake in a Multiethnic Cohort

Frankenfeld CL, Hullar MA, Maskarinec G, Monroe KR, Shepherd J, Franke AA, Randolph TW, Wilkens LR, Boushey CJ, Marchand LL, Lim U, Lampe JW

Journal of the Academy of Nutrition and Dietetics, 122, 78-98 (2021)

Deep Learning Predicts Interval and Screening-detected Cancer from Screening Mammograms: A Case-Case-Control Study in 6369 Women

Zhu X, Wolfgruber T, Leong LT, Jensen MR, Scott CG, Winham SJ, Sadowski P, Vachon CM, Kerlikowske K, Shepherd J

Radiology, 301, 550-558 (2021)

Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy

Bodelón C, Mullooly M, Pfeiffer RM, Fan S, Abubakar M, Lenz PH, …, Shepherd J, et al.

Breast Cancer Research, 23, 105 (2021)

Effect of excessive gestational weight on daughters’ breast density at the end of puberty onset

López A, Garmendia ML, Shepherd J, Michels KB, Corvalán C, Pereira A

Scientific Reports, 10, 6636 (2020)

Three compartment breast machine learning model for improving computer-aided detection

Leong LT, Giger ML, Drukker K, Kerlikowske K, Joe BN, Greenwood H, Malkov S, Niell BL, Shepherd J

Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy

Hada M, Oh H, Fan S, Falk RT, Geller BM, Vacek PM, …, Shepherd J, et al.

Journal of Clinical Medicine, 9, 245 (2020)

Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche

Michels KB, Keller K, Pereira A, Kim CE, Santos JL, Shepherd J, Corvalán C, Binder AM

Breast Cancer Research, 22, 104 (2020)

Distinct phenotypic characteristics of normal-weight adults at risk of developing cardiovascular and metabolic diseases

Stanley A, Schuna JM, Yang S, Kennedy S, Heo M, Wong MC, Shepherd J, Heymsfield SB

American Journal of Clinical Nutrition, 112, 967-978 (2020)

Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217

Northey JJ, Barrett A, Acerbi I, Hayward M, Talamantes S, Dean I, …, Shepherd J, et al.

Journal of Clinical Investigation, 130, 5721-5737 (2020)

Using Digital Pathology to Understand Epithelial Characteristics of Benign Breast Disease among Women Undergoing Diagnostic Image-Guided Breast Biopsy

Mullooly M, Puvanesarajah S, Fan S, Pfeiffer RM, Olsson LT, Hada M, …, Shepherd J, et al.

Cancer Prevention Research, 12, 861-870 (2019)

Derived mammographic masking measures based on simulated lesions predict the risk of interval cancer after controlling for known risk factors: a case‐case analysis

Hinton B, Ma L, Mahmoudzadeh AP, Malkov S, Fan B, Greenwood H, Joe BN, Lee V, Strand F, Kerlikowske K, Shepherd J

Medical Physics, 46, 1309-1316 (2019)

Association of Imaging-Based Body Fat Distribution and Mammographic Density in the Multiethnic Cohort Adiposity Phenotype Study

Maskarinec G, Ciba M, Ju D, Shepherd J, Ernst T, Wu AH, Monroe KR, Lim U, Wilkens LR, Marchand LL

Cancer Epidemiology Biomarkers & Prevention, 29, 352-358 (2019)

Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

Hada M, Oh H, Pfeiffer RM, Falk RT, Fan S, Mullooly M, …, Shepherd J, et al.

Breast Cancer Research, 21, 81 (2019)

Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study

Strand F, Azavedo E, Hellgren R, Humphreys K, Eriksson M, Shepherd J, Hall P, Czene K

Breast Cancer Research, 21, 8 (2019)

Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer

Brandt KR, Scott CG, Miglioretti DL, Jensen MR, Mahmoudzadeh AP, Hruska CB, Ma L, Wu F, Cummings SR, Norman AD, Engmann NJ, Shepherd J, Winham SJ, Kerlikowske K, Vachon CM

Breast Cancer Research, 21, 118 (2019)

Deep learning networks find unique mammographic differences in previous negative mammograms between interval and screen-detected cancers: a case-case study

Hinton B, Ma L, Mahmoudzadeh AP, Malkov S, Fan B, Greenwood H, Joe BN, Lee V, Kerlikowske K, Shepherd J

Cancer Imaging, 19, 41 (2019)

Measurement challenge: protocol for international case–control comparison of mammographic measures that predict breast cancer risk

Dench EK, Bond‐Smith D, Darcey E, Lee G, Aung YK, Chan A, …, Shepherd J, et al.

BMJ Open, 9, e031041 (2019)

Application of convolutional neural networks to breast biopsies to delineate tissue correlates of mammographic breast density

Mullooly M, Bejnordi BE, Pfeiffer RM, Fan S, Palakal M, Hada M, …, Shepherd J, et al.

npj Breast Cancer, 5, 43 (2019)

Longitudinal Changes in Volumetric Breast Density in Healthy Women across the Menopausal Transition

Engmann NJ, Scott CG, Jensen MR, Winham SJ, Ma L, Brandt KR, …, Shepherd J, et al.

Cancer Epidemiology Biomarkers & Prevention, 28, 1324-1330 (2019)

Combined effect of volumetric breast density and body mass index on breast cancer risk

Engmann NJ, Scott CG, Jensen MR, Winham SJ, Miglioretti DL, Ma L, …, Shepherd J, et al.

Breast Cancer Research and Treatment, 177, 165-173 (2019)

Pubertal timing and breast density in young women: a prospective cohort study

Houghton LC, Jung S, Troisi R, LeBlanc ES, Snetselaar L, Hylton NM, Klifa C, Horn LV, Paris K, Shepherd J, Hoover RN, Dorgan JF

Breast Cancer Research, 21, 122 (2019)

Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype

Shieh Y, Scott CG, Jensen MR, Norman AD, Bertrand KA, Pankratz VS, Brandt KR, Visscher DW, Shepherd J, Tamimi RM, Vachon CM, Kerlikowske K

Breast Cancer Research, 21, 48 (2019)

Deep learning methods aid in predicting risk of interval cancer

Hinton B, Shepherd J, Kerlikowske K, Joe BN, Greenwood H, Ma L

Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls

Binder AM, Stiemsma LT, Keller K, Otterdijk SDV, Mericq V, Pereira A, Santos JL, Shepherd J, Michels KB

Clinical Epigenetics, 10, 122 (2018)

Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women

Jung S, Goloubeva O, Hylton NM, Klifa C, LeBlanc ES, Shepherd J, Snetselaar L, Horn LV, Dorgan JF

Cancer Causes & Control, 29, 631-642 (2018)

Does mammographic density mediate risk factor associations with breast cancer? An analysis by tumor characteristics

Rice MS, Tamimi RM, Bertrand KA, Scott CG, Jensen MR, Norman AD, …, Shepherd J, et al.

Breast Cancer Research and Treatment, 170, 129-141 (2018)

Combined Benefit of Quantitative Three-Compartment Breast Image Analysis and Mammography Radiomics in the Classification of Breast Masses in a Clinical Data Set

Drukker K, Giger ML, Joe BN, Kerlikowske K, Greenwood H, Drukteinis JS, Niell BL, Fan B, Malkov S, Avila J, Kazemi L, Shepherd J

Radiology, 290, 621-628 (2018)

Prepubertal and Pubertal Endocrine-Disrupting Chemical Exposure and Breast Density among Chilean Adolescents

Binder AM, Corvalán C, Pereira A, Calafat AM, Ye X, Shepherd J, Michels KB

Cancer Epidemiology Biomarkers & Prevention, 27, 1491-1499 (2018)

Automated and Clinical Breast Imaging Reporting and Data System Density Measures Predict Risk for Screen-Detected and Interval Cancers

Kerlikowske K, Scott CG, Mahmoudzadeh AP, Ma L, Winham SJ, Jensen MR, Wu F, Malkov S, Pankratz VS, Cummings SR, Shepherd J, Brandt KR, Miglioretti DL, Vachon CM

Annals of Internal Medicine, 168, 757-765 (2018)

Interaction of mammographic breast density with menopausal status and postmenopausal hormone use in relation to the risk of aggressive breast cancer subtypes

Yaghjyan L, Tamimi RM, Bertrand KA, Scott CG, Jensen MR, Pankratz VS, …, Shepherd J, et al.

Breast Cancer Research and Treatment, 165, 421-431 (2017)

Determinants of volumetric breast density in Chilean premenopausal women

Pereira A, Garmendia ML, Uauy R, Neira P, López‐Arana S, Malkov S, Shepherd J

Breast Cancer Research and Treatment, 162, 343-352 (2017)

FRAX-based Estimates of 10-year Probability of Hip and Major Osteoporotic Fracture Among Adults Aged 40 and Over: United States, 2013 and 2014.

Looker AC, Isfahani NS, Fan B, Shepherd J

National Health Statistics Reports, , 1-16 (2017)

Combining quantitative and qualitative breast density measures to assess breast cancer risk

Kerlikowske K, Ma L, Scott CG, Mahmoudzadeh AP, Jensen MR, Sprague BL, Henderson LM, Pankratz VS, Cummings SR, Miglioretti DL, Vachon CM, Shepherd J

Breast Cancer Research, 19, 97 (2017)

Longitudinal Changes in Volumetric Breast Density with Tamoxifen and Aromatase Inhibitors

Engmann NJ, Scott CG, Jensen MR, Ma L, Brandt KR, Mahmoudzadeh AP, …, Shepherd J, et al.

Cancer Epidemiology Biomarkers & Prevention, 26, 930-937 (2017)

Faster ticking rate of the epigenetic clock is associated with faster pubertal development in girls

Binder AM, Corvalán C, Mericq V, Pereira A, Santos JL, Horvath S, Shepherd J, Michels KB

Epigenetics, 13, 85-94 (2017)

Do Women with Low Breast Density Have Regionally High Breast Density?

Mahmoudzadeh AP, Malkov S, Hinton B, Sprague BL, Kerlikowske K, Shepherd J

Lecture notes in computer science, , 548-553 (2016)

Longitudinal fluctuation in mammographic percent density differentiates between interval and screen‐detected breast cancer

Strand F, Humphreys K, Eriksson M, Li J, Andersson T, Törnberg S, Azavedo E, Shepherd J, Hall P, Czene K

International Journal of Cancer, 140, 34-40 (2016)

Relation of Serum Estrogen Metabolites with Terminal Duct Lobular Unit Involution Among Women Undergoing Diagnostic Image-Guided Breast Biopsy

Oh H, Khodr ZG, Sherman ME, Palakal M, Pfeiffer RM, Linville L, …, Shepherd J, et al.

Hormones and Cancer, 7, 305-315 (2016)

Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and terminal duct lobular unit involution of the breast: a cross-sectional study of women with benign breast disease

Horne HN, Sherman ME, Pfeiffer RM, Figueroa JD, Khodr ZG, Falk RT, …, Shepherd J, et al.

Breast Cancer Research, 18, 24 (2016)

Novel mammographic image features differentiate between interval and screen-detected breast cancer: a case-case study

Strand F, Humphreys K, Cheddad A, Törnberg S, Azavedo E, Shepherd J, Hall P, Czene K

Breast Cancer Research, 18, 100 (2016)

Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis

Felix AS, Lenz PH, Pfeiffer RM, Hewitt SM, Morris J, Patel DA, …, Shepherd J, et al.

Breast Cancer Research, 18, 88 (2016)

Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status

Malkov S, Shepherd J, Scott CG, Tamimi RM, Ma L, Bertrand KA, Couch FJ, Jensen MR, Mahmoudzadeh AP, Fan B, Norman AD, Brandt KR, Pankratz VS, Vachon CM, Kerlikowske K

Breast Cancer Research, 18, 122 (2016)

Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy

Bodelón C, Heaphy CM, Meeker AK, Geller BM, Vacek PM, Weaver DL, Chicoine RE, Shepherd J, Mahmoudzadeh AP, Patel D, Brinton LA, Sherman ME, Gierach GL

BMC Cancer, 15, 823 (2015)

Relationship of Serum Estrogens and Metabolites with Area and Volume Mammographic Densities

Gierach GL, Patel DA, Falk RT, Pfeiffer RM, Geller BM, Vacek PM, …, Shepherd J, et al.

Hormones and Cancer, 6, 107-119 (2015)

Adolescent endogenous sex hormones and breast density in early adulthood

Jung S, Egleston BL, Chandler DW, Horn LV, Hylton NM, Klifa CC, Lasser NL, LeBlanc ES, Paris K, Shepherd J, Snetselaar L, Stanczyk FZ, Stevens VJ, Dorgan JF

Breast Cancer Research, 17, 77 (2015)

Genetic Risk Scores Implicated in Adult Bone Fragility Associate With Pediatric Bone Density

Mitchell JA, Chesi A, Elci OU, McCormack SE, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd J, Kelly A, Grant SF, Zemel BS

Journal of Bone and Mineral Research, 31, 789-795 (2015)

The Effect of Change in Body Mass Index on Volumetric Measures of Mammographic Density

Hart V, Reeves KW, Sturgeon SR, Reich NG, Sievert LL, Kerlikowske K, Ma L, Shepherd J, Tice JA, Mahmoudzadeh AP, Malkov S, Sprague BL

Cancer Epidemiology Biomarkers & Prevention, 24, 1724-1730 (2015)

Sex and Ethnic Differences in the Association of Obesity With Risk of Hepatocellular Carcinoma

Setiawan VW, Lim U, Lipworth L, Lu SC, Shepherd J, Ernst T, Wilkens LR, Henderson BE, Marchand LL

Clinical Gastroenterology and Hepatology, 14, 309-316 (2015)

Body fatness during childhood and adolescence and breast density in young women: a prospective analysis

Bertrand KA, Baer HJ, Orav EJ, Klifa C, Shepherd J, Horn LV, Snetselaar L, Stevens VJ, Hylton NM, Dorgan JF

Breast Cancer Research, 17, 95 (2015)

Dense and Nondense Mammographic Area and Risk of Breast Cancer by Age and Tumor Characteristics

Bertrand KA, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Norman AD, …, Shepherd J, et al.

Cancer Epidemiology Biomarkers & Prevention, 24, 798-809 (2015)

Relationship of Terminal Duct Lobular Unit Involution of the Breast with Area and Volume Mammographic Densities

Gierach GL, Patel DA, Pfeiffer RM, Figueroa JD, Linville L, Papathomas D, …, Shepherd J, et al.

Cancer Prevention Research, 9, 149-158 (2015)

Fracture Risk Prediction by Non-BMD DXA Measures: the 2015 ISCD Official Positions Part 1: Hip Geometry

Broy SB, Cauley JA, Lewiecki M, Schousboe JT, Shepherd J, Leslie WD

Journal of Clinical Densitometry, 18, 287-308 (2015)

Comparison of Clinical and Automated Breast Density Measurements: Implications for Risk Prediction and Supplemental Screening

Brandt KR, Scott CG, Ma L, Mahmoudzadeh AP, Jensen MR, Whaley DH, Wu F, Malkov S, Hruska CB, Norman AD, Heine J, Shepherd J, Pankratz VS, Kerlikowske K, Vachon CM

Radiology, 279, 710-719 (2015)

Executive Summary of the 2015 ISCD Position Development Conference on Advanced Measures From DXA and QCT: Fracture Prediction Beyond BMD

Shepherd J, Schousboe JT, Broy SB, Engelke K, Leslie WD

Journal of Clinical Densitometry, 18, 274-286 (2015)

Fracture Risk Prediction by Non-BMD DXA Measures: the 2015 ISCD Official Positions Part 2: Trabecular Bone Score

Silva BC, Broy SB, Boutroy S, Schousboe JT, Shepherd J, Leslie WD

Journal of Clinical Densitometry, 18, 309-330 (2015)

Roles of biologic breast tissue composition and quantitative image analysis of mammographic images in breast tumor characterization

Drukker K, Giger ML, Duewer F, Malkov S, Flowers CI, Joe BN, Kerlikowske K, Drukteinis JS, Shepherd J

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE, 9035, 90351U (2014)

Automated Volumetric Breast Density Derived by Statistical Model Approach

Malkov S, Mahmoudzadeh AP, Kerlikowske K, Shepherd J

Lecture notes in computer science, , 257-264 (2014)

Enhancement of Mammographic Density Measures in Breast Cancer Risk Prediction

Cheddad A, Czene K, Shepherd J, Li J, Hall P, Humphreys K

Cancer Epidemiology Biomarkers & Prevention, 23, 1314-1323 (2014)

Endogenous Sex Hormones and Breast Density in Young Women

Jung S, Stanczyk FZ, Egleston BL, Snetselaar L, Stevens VJ, Shepherd J, Horn LV, LeBlanc ES, Paris K, Klifa C, Dorgan JF

Cancer Epidemiology Biomarkers & Prevention, 24, 369-378 (2014)

Dietary Energy Density Is Positively Associated with Breast Density among Young Women

Jones JA, Hartman TJ, Klifa C, Coffman DL, Mitchell DC, Vernarelli JA, Snetselaar L, Horn LV, Stevens VJ, Robson AM, Himes JH, Shepherd J, Dorgan JF

Journal of the Academy of Nutrition and Dietetics, 115, 353-359 (2014)

First pregnancy events and future breast density: modification by age at first pregnancy and specific VEGF and IGF1R gene variants

Prebil LA, Ereman R, Powell M, Jamshidian F, Kerlikowske K, Shepherd J, Hurlbert M, Benz CC

Cancer Causes & Control, 25, 859-868 (2014)

Comparison of Mammographic Density Assessed as Volumes and Areas among Women Undergoing Diagnostic Image-Guided Breast Biopsy

Gierach GL, Geller BM, Shepherd J, Patel DA, Vacek PM, Weaver DL, Chicoine RE, Pfeiffer RM, Fan B, Mahmoudzadeh AP, Wang J, Johnson JM, Herschorn SD, Brinton LA, Sherman ME

Cancer Epidemiology Biomarkers & Prevention, 23, 2338-2348 (2014)

Automated Measurement of Volumetric Mammographic Density: A Tool for Widespread Breast Cancer Risk Assessment

Brand JS, Czene K, Shepherd J, Leifland K, Heddson B, Sundbom A, Eriksson M, Li J, Humphreys K, Hall P

Cancer Epidemiology Biomarkers & Prevention, 23, 1764-1772 (2014)

Digital mammographic density and breast cancer risk: a case–control study of six alternative density assessment methods

Eng A, Gallant Z, Shepherd J, McCormack V, Li J, Dowsett M, Vinnicombe S, Allen S, dos‐Santos‐Silva I

Breast Cancer Research, 16, 439 (2014)

High mammographic density in women of Ashkenazi Jewish descent

Caswell‐Jin JL, Kerlikowske K, Shepherd J, Cummings SR, Hu D, Huntsman S, Ziv E

Breast Cancer Research, 15, R40 (2013)

Menstrual and reproductive characteristics and breast density in young women

Dorgan JF, Klifa C, Deshmukh S, Egleston BL, Shepherd J, Kwiterovich PO, Horn LV, Snetselaar L, Stevens VJ, Robson AM, Lasser NL, Hylton NM

Cancer Causes & Control, 24, 1973-1983 (2013)

Agreement of Mammographic Measures of Volumetric Breast Density to MRI

Wang J, Azziz A, Fan B, Malkov S, Klifa C, Newitt DC, Yitta S, Hylton NM, Kerlikowske K, Shepherd J

PLoS ONE, 8, e81653 (2013)

Mammographic density and risk of breast cancer by age and tumor characteristics

Bertrand KA, Tamimi RM, Scott CG, Jensen MR, Pankratz VS, Visscher DW, …, Shepherd J, et al.

Breast Cancer Research, 15, R104 (2013)

Do fatty breasts increase or decrease breast cancer risk?

Shepherd J, Kerlikowske K

Breast Cancer Research, 14, 102 (2012)

A comparison of breast density measures between mothers and adolescent daughters

Maskarinec G, Morimoto Y, Daida YG, Shepherd J, Novotny R

BMC Cancer, 11, 330 (2011)

Volume of Mammographic Density and Risk of Breast Cancer

Shepherd J, Kerlikowske K, Ma L, Duewer F, Fan B, Wang J, Malkov S, Vittinghoff E, Cummings SR

Cancer Epidemiology Biomarkers & Prevention, 20, 1473-1482 (2011)

Comparison of Subregional Breast Density with Whole Breast Density

Malkov S, Ma L, Kerlikowske K, Wang J, Cummings S, Shepherd J

Lecture notes in computer science, , 402-407 (2010)

Adolescent Diet and Subsequent Serum Hormones, Breast Density, and Bone Mineral Density in Young Women: Results of the Dietary Intervention Study in Children Follow-up Study

Dorgan JF, Liu L, Klifa C, Hylton NM, Shepherd J, Stanczyk FZ, et al.

Cancer Epidemiology Biomarkers & Prevention, 19, 1545-1556 (2010)

Magnetic resonance imaging for secondary assessment of breast density in a high-risk cohort

Klifa C, Carballido‐Gamio J, Wilmes LJ, Laprie A, Shepherd J, Gibbs J, Fan B, Noworolski SM, Hylton NM

Magnetic Resonance Imaging, 28, 8-15 (2009)

Prevention of Breast Cancer in Postmenopausal Women: Approaches to Estimating and Reducing Risk

Cummings SR, Tice JA, Bauer SR, Browner WS, Cuzick J, Ziv E, Vogel V, Shepherd J, Vachon C, Smith‐Bindman R, Kerlikowske K

JNCI Journal of the National Cancer Institute, 101, 384-398 (2009)

Breast Density Assessment in Adolescent Girls Using Dual-Energy X-ray Absorptiometry: A Feasibility Study

Shepherd J, Malkov S, Fan B, Laidevant A, Novotny R, Maskarinec G

Cancer Epidemiology Biomarkers & Prevention, 17, 1709-1713 (2008)

Novel use of Single X-Ray Absorptiometry for Measuring Breast Density

Shepherd J, Hervé L, Landau J, Fan B, Kerlikowske K, Cummings S

Technology in Cancer Research & Treatment, 4, 173-182 (2005)

Are Breast Density and Bone Mineral Density Independent Risk Factors for Breast Cancer?

Kerlikowske K, Shepherd J, Creasman JM, Tice JA, Ziv E, Cummings SR

JNCI Journal of the National Cancer Institute, 97, 368-374 (2005)

Quantification of breast tissue index from MR data using fuzzy clustering

Klifa C, Carballido‐Gamio J, Wilmes LJ, Laprie A, Lobo C, DeMicco E, Watkins MW, Shepherd J, Gibbs J, Hylton NM

Mammographic Density and Estrogen Receptor Status of Breast Cancer

Ziv E, Tice JA, Smith‐Bindman R, Shepherd J, Cummings SR, Kerlikowske K

Cancer Epidemiology Biomarkers & Prevention, 13, 2090-2095 (2004)

Accuracy of mammographic breast density analysis: results of formal operator training.

Prevrhal S, Shepherd J, Smith‐Bindman R, Cummings SR, Kerlikowske K

Cancer Epidemiology, Biomarkers & Prevention, 11, 1389-93 (2002)