High dietary total energy intake and energy density are associated with girls’ breast density during puberty
Carrasco C, Garmendia ML, Martínez-Arroyo A, Shepherd J, Pereira A
European Journal of Nutrition, 64, 245 (2025)
Cancer — Publications
The lab’s cancer research surfaces under three research-area tags in our taxonomy. Each section below filters to papers carrying one of those tags. Some papers appear in more than one section when they cross topics.
Breast Density
113 publications · sorted by year, newest first.
2025
Prediction of mammographic breast density based on clinical breast ultrasound images using deep learning: a retrospective analysis
Bunnell A, Valdez D, Wolfgruber T, Quon BK, Hung K, Hernandez BY, Seto TB, Killeen J, Miyoshi M, Sadowski P, Shepherd J
The Lancet Regional Health - Americas, 46, 101096 (2025)
2024
The Associations between Intakes of One-Carbon Metabolism–Related Vitamins and Breast Density among Young Women
Han E, Horn LV, Snetselaar L, Shepherd J, Park YJ, Kim H, Jung S, Dorgan JF
Cancer Epidemiology Biomarkers & Prevention, 33, 567-575 (2024)
The Prospective Association between Early Life Growth and Breast Density in Young Adult Women
Lloyd R, Pirikahu S, Walter EJ, Cadby G, Warrington NM, Perera D, Hickey M, Saunders C, Hackmann MJ, Sampson DD, Shepherd J, Lilge L, Stone J
Cancers, 16, 2418 (2024)
Time‐specific impact of trace metals on breast density of adolescent girls in Santiago, Chile
Kim CE, Pereira A, Binder AM, Amarasiriwardena C, Shepherd J, Corvalán C, Michels KB
International Journal of Cancer, 155, 627-636 (2024)
Breast composition during and after puberty: the Chilean Growth and Obesity Cohort Study
Pereira A, Garmendia ML, Leiva V, Corvalán C, Michels KB, Shepherd J
Breast Cancer Research, 26, 45 (2024)
The distribution of breast density in women aged 18 years and older
Perera D, Pirikahu S, Walter J, Cadby G, Darcey E, Lloyd R, Hickey M, Saunders C, Hackmann MJ, Sampson DD, Shepherd J, Lilge L, Stone J
Breast Cancer Research and Treatment, 205, 521-531 (2024)
2023
Untargeted serum metabolomic profiles and breast density in young women
Jung S, Silva S, Dallal CM, LeBlanc ES, Paris K, Shepherd J, Snetselaar L, Horn LV, Zhang Y, Dorgan JF
Cancer Causes & Control, 35, 323-334 (2023)
Time-specific impact of mono-benzyl phthalate (MBzP) and perfluorooctanoic acid (PFOA) on breast density of a Chilean adolescent Cohort
Kim CE, Binder AM, Corvalán C, Pereira A, Shepherd J, Calafat AM, Botelho JC, Hampton JM, Trentham‐Dietz A, Michels KB
Environment International, 181, 108241 (2023)
Alternative methods to measure breast density in younger women
Lloyd R, Pirikahu S, Walter J, Cadby G, Darcey E, Perera D, Hickey M, Saunders C, Karnowski K, Sampson DD, Shepherd J, Lilge L, Stone J
British Journal of Cancer, 128, 1701-1709 (2023)
2022
Habitual Phytoestrogen Intake Is Associated with Breast Composition in Girls at 2 Years after Menarche Onset
Lesser C, Mericq V, Reyes M, Garmendia ML, Shepherd JA, Michels KB, Corvalán C, Pereira A
Cancer Epidemiology Biomarkers & Prevention, 31, 1334-1340 (2022)
Sugar-sweetened beverage consumption and breast composition in a longitudinal study of Chilean girls
Yoon L, Corvalán C, Pereira A, Shepherd J, Michels KB
Breast Cancer Research, 24, 3 (2022)
Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls
Yoon L, Binder AM, Pereira A, Calafat AM, Shepherd J, Corvalán C, Michels KB
Environment International, 170, 107586 (2022)
A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women
Kehm RD, Walter EJ, Pereira A, White M, Oskar S, Michels KB, Shepherd J, Lilge L, Terry MB
Scientific Reports, 12, 13547 (2022)
2021
Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk
Rustagi AS, Scott CG, Winham SJ, Brandt KR, Norman AD, Jensen MR, Shepherd J, Hruska CB, Heine J, Pankratz VS, Kerlikowske K, Vachon CM
JNCI Cancer Spectrum, 5, (2021)
Dual-energy three-compartment breast imaging for compositional biomarkers to improve detection of malignant lesions
Leong LT, Malkov S, Drukker K, Niell BL, Sadowski P, Wolfgruber T, Greenwood H, Joe BN, Kerlikowske K, Giger ML, Shepherd J
Communications Medicine, 1, 29 (2021)
Mammographic Variation Measures, Breast Density, and Breast Cancer Risk
Heine J, Fowler E, Scott CG, Jensen MR, Shepherd J, Hruska CB, Winham SJ, Brandt KR, Wu F, Norman AD, Pankratz VS, Miglioretti DL, Kerlikowske K, Vachon CM
American Journal of Roentgenology, 217, 326-335 (2021)
Association of mammographic density measures and breast cancer “intrinsic” molecular subtypes
Kleinstern G, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Bertrand KA, …, Shepherd J, et al.
Breast Cancer Research and Treatment, 187, 215-224 (2021)
Deep Learning Predicts Interval and Screening-detected Cancer from Screening Mammograms: A Case-Case-Control Study in 6369 Women
Zhu X, Wolfgruber T, Leong LT, Jensen MR, Scott CG, Winham SJ, Sadowski P, Vachon CM, Kerlikowske K, Shepherd J
Radiology, 301, 550-558 (2021)
Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy
Bodelón C, Mullooly M, Pfeiffer RM, Fan S, Abubakar M, Lenz PH, …, Shepherd J, et al.
Breast Cancer Research, 23, 105 (2021)
2020
Effect of excessive gestational weight on daughters’ breast density at the end of puberty onset
López A, Garmendia ML, Shepherd J, Michels KB, Corvalán C, Pereira A
Scientific Reports, 10, 6636 (2020)
Three compartment breast machine learning model for improving computer-aided detection
Leong LT, Giger ML, Drukker K, Kerlikowske K, Joe BN, Greenwood H, Malkov S, Niell BL, Shepherd J
Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy
Hada M, Oh H, Fan S, Falk RT, Geller BM, Vacek PM, …, Shepherd J, et al.
Journal of Clinical Medicine, 9, 245 (2020)
Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche
Michels KB, Keller K, Pereira A, Kim CE, Santos JL, Shepherd J, Corvalán C, Binder AM
Breast Cancer Research, 22, 104 (2020)
Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217
Northey JJ, Barrett A, Acerbi I, Hayward M, Talamantes S, Dean I, …, Shepherd J, et al.
Journal of Clinical Investigation, 130, 5721-5737 (2020)
2019
Using Digital Pathology to Understand Epithelial Characteristics of Benign Breast Disease among Women Undergoing Diagnostic Image-Guided Breast Biopsy
Mullooly M, Puvanesarajah S, Fan S, Pfeiffer RM, Olsson LT, Hada M, …, Shepherd J, et al.
Cancer Prevention Research, 12, 861-870 (2019)
Derived mammographic masking measures based on simulated lesions predict the risk of interval cancer after controlling for known risk factors: a case‐case analysis
Hinton B, Ma L, Mahmoudzadeh AP, Malkov S, Fan B, Greenwood H, Joe BN, Lee V, Strand F, Kerlikowske K, Shepherd J
Medical Physics, 46, 1309-1316 (2019)
Association of Imaging-Based Body Fat Distribution and Mammographic Density in the Multiethnic Cohort Adiposity Phenotype Study
Maskarinec G, Ciba M, Ju D, Shepherd J, Ernst T, Wu AH, Monroe KR, Lim U, Wilkens LR, Marchand LL
Cancer Epidemiology Biomarkers & Prevention, 29, 352-358 (2019)
Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy
Hada M, Oh H, Pfeiffer RM, Falk RT, Fan S, Mullooly M, …, Shepherd J, et al.
Breast Cancer Research, 21, 81 (2019)
Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study
Strand F, Azavedo E, Hellgren R, Humphreys K, Eriksson M, Shepherd J, Hall P, Czene K
Breast Cancer Research, 21, 8 (2019)
Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer
Brandt KR, Scott CG, Miglioretti DL, Jensen MR, Mahmoudzadeh AP, Hruska CB, Ma L, Wu F, Cummings SR, Norman AD, Engmann NJ, Shepherd J, Winham SJ, Kerlikowske K, Vachon CM
Breast Cancer Research, 21, 118 (2019)
Deep learning networks find unique mammographic differences in previous negative mammograms between interval and screen-detected cancers: a case-case study
Hinton B, Ma L, Mahmoudzadeh AP, Malkov S, Fan B, Greenwood H, Joe BN, Lee V, Kerlikowske K, Shepherd J
Cancer Imaging, 19, 41 (2019)
Measurement challenge: protocol for international case–control comparison of mammographic measures that predict breast cancer risk
Dench EK, Bond‐Smith D, Darcey E, Lee G, Aung YK, Chan A, …, Shepherd J, et al.
BMJ Open, 9, e031041 (2019)
Application of convolutional neural networks to breast biopsies to delineate tissue correlates of mammographic breast density
Mullooly M, Bejnordi BE, Pfeiffer RM, Fan S, Palakal M, Hada M, …, Shepherd J, et al.
npj Breast Cancer, 5, 43 (2019)
Longitudinal Changes in Volumetric Breast Density in Healthy Women across the Menopausal Transition
Engmann NJ, Scott CG, Jensen MR, Winham SJ, Ma L, Brandt KR, …, Shepherd J, et al.
Cancer Epidemiology Biomarkers & Prevention, 28, 1324-1330 (2019)
Combined effect of volumetric breast density and body mass index on breast cancer risk
Engmann NJ, Scott CG, Jensen MR, Winham SJ, Miglioretti DL, Ma L, …, Shepherd J, et al.
Breast Cancer Research and Treatment, 177, 165-173 (2019)
Pubertal timing and breast density in young women: a prospective cohort study
Houghton LC, Jung S, Troisi R, LeBlanc ES, Snetselaar L, Hylton NM, Klifa C, Horn LV, Paris K, Shepherd J, Hoover RN, Dorgan JF
Breast Cancer Research, 21, 122 (2019)
Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype
Shieh Y, Scott CG, Jensen MR, Norman AD, Bertrand KA, Pankratz VS, Brandt KR, Visscher DW, Shepherd J, Tamimi RM, Vachon CM, Kerlikowske K
Breast Cancer Research, 21, 48 (2019)
2018
Deep learning methods aid in predicting risk of interval cancer
Hinton B, Shepherd J, Kerlikowske K, Joe BN, Greenwood H, Ma L
Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls
Binder AM, Stiemsma LT, Keller K, Otterdijk SDV, Mericq V, Pereira A, Santos JL, Shepherd J, Michels KB
Clinical Epigenetics, 10, 122 (2018)
Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women
Jung S, Goloubeva O, Hylton NM, Klifa C, LeBlanc ES, Shepherd J, Snetselaar L, Horn LV, Dorgan JF
Cancer Causes & Control, 29, 631-642 (2018)
Does mammographic density mediate risk factor associations with breast cancer? An analysis by tumor characteristics
Rice MS, Tamimi RM, Bertrand KA, Scott CG, Jensen MR, Norman AD, …, Shepherd J, et al.
Breast Cancer Research and Treatment, 170, 129-141 (2018)
Combined Benefit of Quantitative Three-Compartment Breast Image Analysis and Mammography Radiomics in the Classification of Breast Masses in a Clinical Data Set
Drukker K, Giger ML, Joe BN, Kerlikowske K, Greenwood H, Drukteinis JS, Niell BL, Fan B, Malkov S, Avila J, Kazemi L, Shepherd J
Radiology, 290, 621-628 (2018)
Prepubertal and Pubertal Endocrine-Disrupting Chemical Exposure and Breast Density among Chilean Adolescents
Binder AM, Corvalán C, Pereira A, Calafat AM, Ye X, Shepherd J, Michels KB
Cancer Epidemiology Biomarkers & Prevention, 27, 1491-1499 (2018)
Automated and Clinical Breast Imaging Reporting and Data System Density Measures Predict Risk for Screen-Detected and Interval Cancers
Kerlikowske K, Scott CG, Mahmoudzadeh AP, Ma L, Winham SJ, Jensen MR, Wu F, Malkov S, Pankratz VS, Cummings SR, Shepherd J, Brandt KR, Miglioretti DL, Vachon CM
Annals of Internal Medicine, 168, 757-765 (2018)
2017
Deep learning and three-compartment breast imaging in breast cancer diagnosis
Drukker K, Huynh BQ, Giger ML, Malkov S, Avila J, Fan B, Joe BN, Kerlikowske K, Drukteinis JS, Kazemi L, Pereira M, Shepherd J
Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE, 10134, 101341F (2017)
Interaction of mammographic breast density with menopausal status and postmenopausal hormone use in relation to the risk of aggressive breast cancer subtypes
Yaghjyan L, Tamimi RM, Bertrand KA, Scott CG, Jensen MR, Pankratz VS, …, Shepherd J, et al.
Breast Cancer Research and Treatment, 165, 421-431 (2017)
Determinants of volumetric breast density in Chilean premenopausal women
Pereira A, Garmendia ML, Uauy R, Neira P, López‐Arana S, Malkov S, Shepherd J
Breast Cancer Research and Treatment, 162, 343-352 (2017)
Dairy intake in relation to breast and pubertal development in Chilean girls,
Gaskins AJ, Pereira A, Quintiliano DA, Shepherd J, Uauy R, Corvalán C, Michels KB
American Journal of Clinical Nutrition, 105, 1166-1175 (2017)
Combining quantitative and qualitative breast density measures to assess breast cancer risk
Kerlikowske K, Ma L, Scott CG, Mahmoudzadeh AP, Jensen MR, Sprague BL, Henderson LM, Pankratz VS, Cummings SR, Miglioretti DL, Vachon CM, Shepherd J
Breast Cancer Research, 19, 97 (2017)
Longitudinal Changes in Volumetric Breast Density with Tamoxifen and Aromatase Inhibitors
Engmann NJ, Scott CG, Jensen MR, Ma L, Brandt KR, Mahmoudzadeh AP, …, Shepherd J, et al.
Cancer Epidemiology Biomarkers & Prevention, 26, 930-937 (2017)
Faster ticking rate of the epigenetic clock is associated with faster pubertal development in girls
Binder AM, Corvalán C, Mericq V, Pereira A, Santos JL, Horvath S, Shepherd J, Michels KB
Epigenetics, 13, 85-94 (2017)
2016
Do Women with Low Breast Density Have Regionally High Breast Density?
Mahmoudzadeh AP, Malkov S, Hinton B, Sprague BL, Kerlikowske K, Shepherd J
Lecture notes in computer science, , 548-553 (2016)
A Measure of Regional Mammographic Masking Based on the CDMAM Phantom
Hinton B, Malkov S, Avila J, Fan B, Joe BN, Kerlikowske K, Ma L, Mahmoudzadeh AP, Shepherd J
Lecture notes in computer science, , 525-531 (2016)
Energy Dependence of Water and Lipid Calibration Materials for Three-Compartment Breast Imaging
Avila J, Malkov S, Giger ML, Drukker K, Shepherd J
Lecture notes in computer science, , 554-563 (2016)
Calibration Procedure of Three Component Mammographic Breast Imaging
Malkov S, Avila J, Fan B, Joe BN, Kerlikowske K, Giger ML, Drukker K, Drukteinis JS, Kazemi L, Pereira M, Shepherd J
Lecture notes in computer science, , 211-218 (2016)
Longitudinal fluctuation in mammographic percent density differentiates between interval and screen‐detected breast cancer
Strand F, Humphreys K, Eriksson M, Li J, Andersson T, Törnberg S, Azavedo E, Shepherd J, Hall P, Czene K
International Journal of Cancer, 140, 34-40 (2016)
Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and terminal duct lobular unit involution of the breast: a cross-sectional study of women with benign breast disease
Horne HN, Sherman ME, Pfeiffer RM, Figueroa JD, Khodr ZG, Falk RT, …, Shepherd J, et al.
Breast Cancer Research, 18, 24 (2016)
Novel mammographic image features differentiate between interval and screen-detected breast cancer: a case-case study
Strand F, Humphreys K, Cheddad A, Törnberg S, Azavedo E, Shepherd J, Hall P, Czene K
Breast Cancer Research, 18, 100 (2016)
Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis
Felix AS, Lenz PH, Pfeiffer RM, Hewitt SM, Morris J, Patel DA, …, Shepherd J, et al.
Breast Cancer Research, 18, 88 (2016)
Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status
Malkov S, Shepherd J, Scott CG, Tamimi RM, Ma L, Bertrand KA, Couch FJ, Jensen MR, Mahmoudzadeh AP, Fan B, Norman AD, Brandt KR, Pankratz VS, Vachon CM, Kerlikowske K
Breast Cancer Research, 18, 122 (2016)
2015
Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy
Bodelón C, Heaphy CM, Meeker AK, Geller BM, Vacek PM, Weaver DL, Chicoine RE, Shepherd J, Mahmoudzadeh AP, Patel D, Brinton LA, Sherman ME, Gierach GL
BMC Cancer, 15, 823 (2015)
Relationship of Serum Estrogens and Metabolites with Area and Volume Mammographic Densities
Gierach GL, Patel DA, Falk RT, Pfeiffer RM, Geller BM, Vacek PM, …, Shepherd J, et al.
Hormones and Cancer, 6, 107-119 (2015)
Adolescent endogenous sex hormones and breast density in early adulthood
Jung S, Egleston BL, Chandler DW, Horn LV, Hylton NM, Klifa CC, Lasser NL, LeBlanc ES, Paris K, Shepherd J, Snetselaar L, Stanczyk FZ, Stevens VJ, Dorgan JF
Breast Cancer Research, 17, 77 (2015)
The Effect of Change in Body Mass Index on Volumetric Measures of Mammographic Density
Hart V, Reeves KW, Sturgeon SR, Reich NG, Sievert LL, Kerlikowske K, Ma L, Shepherd J, Tice JA, Mahmoudzadeh AP, Malkov S, Sprague BL
Cancer Epidemiology Biomarkers & Prevention, 24, 1724-1730 (2015)
Body fatness during childhood and adolescence and breast density in young women: a prospective analysis
Bertrand KA, Baer HJ, Orav EJ, Klifa C, Shepherd J, Horn LV, Snetselaar L, Stevens VJ, Hylton NM, Dorgan JF
Breast Cancer Research, 17, 95 (2015)
Dense and Nondense Mammographic Area and Risk of Breast Cancer by Age and Tumor Characteristics
Bertrand KA, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Norman AD, …, Shepherd J, et al.
Cancer Epidemiology Biomarkers & Prevention, 24, 798-809 (2015)
Relationship of Terminal Duct Lobular Unit Involution of the Breast with Area and Volume Mammographic Densities
Gierach GL, Patel DA, Pfeiffer RM, Figueroa JD, Linville L, Papathomas D, …, Shepherd J, et al.
Cancer Prevention Research, 9, 149-158 (2015)
Comparison of Clinical and Automated Breast Density Measurements: Implications for Risk Prediction and Supplemental Screening
Brandt KR, Scott CG, Ma L, Mahmoudzadeh AP, Jensen MR, Whaley DH, Wu F, Malkov S, Hruska CB, Norman AD, Heine J, Shepherd J, Pankratz VS, Kerlikowske K, Vachon CM
Radiology, 279, 710-719 (2015)
2014
Roles of biologic breast tissue composition and quantitative image analysis of mammographic images in breast tumor characterization
Drukker K, Giger ML, Duewer F, Malkov S, Flowers CI, Joe BN, Kerlikowske K, Drukteinis JS, Shepherd J
Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE, 9035, 90351U (2014)
Compositional Three-Component Breast Imaging of Fibroadenoma and Invasive Cancer Lesions: Pilot Study
Malkov S, Duewer F, Kerlikowske K, Drukker K, Giger ML, Shepherd J
Lecture notes in computer science, , 109-114 (2014)
Automated Volumetric Breast Density Derived by Statistical Model Approach
Malkov S, Mahmoudzadeh AP, Kerlikowske K, Shepherd J
Lecture notes in computer science, , 257-264 (2014)
Automated volumetric breast density derived by shape and appearance modeling
Malkov S, Kerlikowske K, Shepherd J
Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE, 9034, 90342T (2014)
Mammographic quantitative image analysis and biologic image composition for breast lesion characterization and classification
Drukker K, Duewer F, Giger ML, Malkov S, Flowers CI, Joe BN, Kerlikowske K, Drukteinis JS, Li H, Shepherd J
Medical Physics, 41, 031915 (2014)
Enhancement of Mammographic Density Measures in Breast Cancer Risk Prediction
Cheddad A, Czene K, Shepherd J, Li J, Hall P, Humphreys K
Cancer Epidemiology Biomarkers & Prevention, 23, 1314-1323 (2014)
Endogenous Sex Hormones and Breast Density in Young Women
Jung S, Stanczyk FZ, Egleston BL, Snetselaar L, Stevens VJ, Shepherd J, Horn LV, LeBlanc ES, Paris K, Klifa C, Dorgan JF
Cancer Epidemiology Biomarkers & Prevention, 24, 369-378 (2014)
Dietary Energy Density Is Positively Associated with Breast Density among Young Women
Jones JA, Hartman TJ, Klifa C, Coffman DL, Mitchell DC, Vernarelli JA, Snetselaar L, Horn LV, Stevens VJ, Robson AM, Himes JH, Shepherd J, Dorgan JF
Journal of the Academy of Nutrition and Dietetics, 115, 353-359 (2014)
First pregnancy events and future breast density: modification by age at first pregnancy and specific VEGF and IGF1R gene variants
Prebil LA, Ereman R, Powell M, Jamshidian F, Kerlikowske K, Shepherd J, Hurlbert M, Benz CC
Cancer Causes & Control, 25, 859-868 (2014)
Comparison of Mammographic Density Assessed as Volumes and Areas among Women Undergoing Diagnostic Image-Guided Breast Biopsy
Gierach GL, Geller BM, Shepherd J, Patel DA, Vacek PM, Weaver DL, Chicoine RE, Pfeiffer RM, Fan B, Mahmoudzadeh AP, Wang J, Johnson JM, Herschorn SD, Brinton LA, Sherman ME
Cancer Epidemiology Biomarkers & Prevention, 23, 2338-2348 (2014)
Automated Measurement of Volumetric Mammographic Density: A Tool for Widespread Breast Cancer Risk Assessment
Brand JS, Czene K, Shepherd J, Leifland K, Heddson B, Sundbom A, Eriksson M, Li J, Humphreys K, Hall P
Cancer Epidemiology Biomarkers & Prevention, 23, 1764-1772 (2014)
Digital mammographic density and breast cancer risk: a case–control study of six alternative density assessment methods
Eng A, Gallant Z, Shepherd J, McCormack V, Li J, Dowsett M, Vinnicombe S, Allen S, dos‐Santos‐Silva I
Breast Cancer Research, 16, 439 (2014)
2013
High mammographic density in women of Ashkenazi Jewish descent
Caswell‐Jin JL, Kerlikowske K, Shepherd J, Cummings SR, Hu D, Huntsman S, Ziv E
Breast Cancer Research, 15, R40 (2013)
Menstrual and reproductive characteristics and breast density in young women
Dorgan JF, Klifa C, Deshmukh S, Egleston BL, Shepherd J, Kwiterovich PO, Horn LV, Snetselaar L, Stevens VJ, Robson AM, Lasser NL, Hylton NM
Cancer Causes & Control, 24, 1973-1983 (2013)
Agreement of Mammographic Measures of Volumetric Breast Density to MRI
Wang J, Azziz A, Fan B, Malkov S, Klifa C, Newitt DC, Yitta S, Hylton NM, Kerlikowske K, Shepherd J
PLoS ONE, 8, e81653 (2013)
Mammographic density and risk of breast cancer by age and tumor characteristics
Bertrand KA, Tamimi RM, Scott CG, Jensen MR, Pankratz VS, Visscher DW, …, Shepherd J, et al.
Breast Cancer Research, 15, R104 (2013)
2012
Improvements and Performance of Diagnostic Compositional Imaging Using a Novel Dual-Energy X-ray Technique
Duewer F, Flowers CI, Kerlikowske K, Malkov S, Joe BN, Shepherd J
Lecture notes in computer science, , 569-574 (2012)
A Calibration Approach for Single-Energy X-ray Absorptiometry Method to Provide Absolute Breast Tissue Composition Accuracy for the Long Term
Malkov S, Wang J, Duewer F, Shepherd J
Lecture notes in computer science, , 769-774 (2012)
Do fatty breasts increase or decrease breast cancer risk?
Shepherd J, Kerlikowske K
Breast Cancer Research, 14, 102 (2012)
Comparison of Hologic’s Quantra Volumetric Assessment to MRI Breast Density
Wang J, Aziz A, Newitt D, Joe BN, Hylton NM, Shepherd J
Lecture notes in computer science, , 619-626 (2012)
Height, adiposity and body fat distribution and breast density in young women
Dorgan JF, Klifa C, Shepherd J, Egleston BL, Kwiterovich PO, Himes JH, Gabriel KP, Horn LV, Snetselaar L, Stevens VJ, Barton B, Robson AM, Lasser NL, Deshmukh S, Hylton NM
Breast Cancer Research, 14, R107 (2012)
2011
A comparison of breast density measures between mothers and adolescent daughters
Maskarinec G, Morimoto Y, Daida YG, Shepherd J, Novotny R
BMC Cancer, 11, 330 (2011)
Puberty, body fat, and breast density in girls of several ethnic groups
Novotny R, Daida YG, Morimoto Y, Shepherd J, Maskarinec G
American Journal of Human Biology, 23, 359-365 (2011)
Volume of Mammographic Density and Risk of Breast Cancer
Shepherd J, Kerlikowske K, Ma L, Duewer F, Fan B, Wang J, Malkov S, Vittinghoff E, Cummings SR
Cancer Epidemiology Biomarkers & Prevention, 20, 1473-1482 (2011)
2010
Comparison of Subregional Breast Density with Whole Breast Density
Malkov S, Ma L, Kerlikowske K, Wang J, Cummings S, Shepherd J
Lecture notes in computer science, , 402-407 (2010)
Comparison of breast density measured by dual energy X-ray absorptiometry with mammographic density among adult women in Hawaii
Maskarinec G, Morimoto Y, Daida YG, Laidevant A, Malkov S, Shepherd J, Novotny R
Cancer Epidemiology, 35, 188-193 (2010)
Adolescent Diet and Subsequent Serum Hormones, Breast Density, and Bone Mineral Density in Young Women: Results of the Dietary Intervention Study in Children Follow-up Study
Dorgan JF, Liu L, Klifa C, Hylton NM, Shepherd J, Stanczyk FZ, et al.
Cancer Epidemiology Biomarkers & Prevention, 19, 1545-1556 (2010)
2009
Compositional breast imaging using a dual‐energy mammography protocol
Laidevant A, Malkov S, Flowers CI, Kerlikowske K, Shepherd J
Medical Physics, 37, 164-174 (2009)
Single x‐ray absorptiometry method for the quantitative mammographic measure of fibroglandular tissue volume
Malkov S, Wang J, Kerlikowske K, Cummings SR, Shepherd J
Medical Physics, 36, 5525-5536 (2009)
Magnetic resonance imaging for secondary assessment of breast density in a high-risk cohort
Klifa C, Carballido‐Gamio J, Wilmes LJ, Laprie A, Shepherd J, Gibbs J, Fan B, Noworolski SM, Hylton NM
Magnetic Resonance Imaging, 28, 8-15 (2009)
Prevention of Breast Cancer in Postmenopausal Women: Approaches to Estimating and Reducing Risk
Cummings SR, Tice JA, Bauer SR, Browner WS, Cuzick J, Ziv E, Vogel V, Shepherd J, Vachon C, Smith‐Bindman R, Kerlikowske K
JNCI Journal of the National Cancer Institute, 101, 384-398 (2009)
2008
Cross-Calibration and Longitudinal Quality Control of Hologic Selenia Full-Field Digital Mammography Systems for Volumetric Breast Density Measurements
Wang J, Malkov S, Fan B, Shepherd J
Lecture notes in computer science, , 740-747 (2008)
Dual-Energy X-Ray Absorptiometry Method Using a Full Field Digital Mammography System
Laidevant A, Malkov S, Au A, Shepherd J
Lecture notes in computer science, , 108-115 (2008)
Improvements to Single Energy Absorptiometry Method for Digital Mammography to Quantify Breast Tissue Density
Malkov S, Wang J, Shepherd J
Lecture notes in computer science, , 1-8 (2008)
Breast Density Assessment in Adolescent Girls Using Dual-Energy X-ray Absorptiometry: A Feasibility Study
Shepherd J, Malkov S, Fan B, Laidevant A, Novotny R, Maskarinec G
Cancer Epidemiology Biomarkers & Prevention, 17, 1709-1713 (2008)
2007
Novel single x-ray absorptiometry method to solve for volumetric breast density in mammograms with paddle tilt
Malkov S, Wang J, Shepherd J
Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE, 6510, 651035 (2007)
Effect of ultra-low-dose transdermal estradiol on breast density in postmenopausal women
Grady D, Vittinghoff E, Lin F, Hanes V, Ensrud KE, Habel LA, Wallace RB, Macer J, Cummings SR, Shepherd J
Menopause The Journal of The North American Menopause Society, 14, 391-396 (2007)
2006
Clinical comparison of a novel breast DXA technique to mammographic density
Shepherd J, Hervé L, Landau J, Fan B, Kerlikowske K, Cummings S
Medical Physics, 33, 1490-1498 (2006)
2005
Novel use of Single X-Ray Absorptiometry for Measuring Breast Density
Shepherd J, Hervé L, Landau J, Fan B, Kerlikowske K, Cummings S
Technology in Cancer Research & Treatment, 4, 173-182 (2005)
Are Breast Density and Bone Mineral Density Independent Risk Factors for Breast Cancer?
Kerlikowske K, Shepherd J, Creasman JM, Tice JA, Ziv E, Cummings SR
JNCI Journal of the National Cancer Institute, 97, 368-374 (2005)
Quantification of breast tissue index from MR data using fuzzy clustering
Klifa C, Carballido‐Gamio J, Wilmes LJ, Laprie A, Lobo C, DeMicco E, Watkins MW, Shepherd J, Gibbs J, Hylton NM
2004
Mammographic Density and Estrogen Receptor Status of Breast Cancer
Ziv E, Tice JA, Smith‐Bindman R, Shepherd J, Cummings SR, Kerlikowske K
Cancer Epidemiology Biomarkers & Prevention, 13, 2090-2095 (2004)
2002
Accuracy of mammographic breast density analysis: results of formal operator training.
Prevrhal S, Shepherd J, Smith‐Bindman R, Cummings SR, Kerlikowske K
Cancer Epidemiology, Biomarkers & Prevention, 11, 1389-93 (2002)
Measurement of Breast Density with Dual X-ray Absorptiometry: Feasibility
Shepherd J, Kerlikowske K, Smith‐Bindman R, Genant HK, Cummings S
Radiology, 223, 554-557 (2002)
Cancer Screening
51 publications · sorted by year, newest first.
2026
An Integrated Academic Oncology Ecosystem for Hawaiʻi and the U.S.-Affiliated Pacific Islands
Lim SJS, Yamauchi H, Yamauchi T, Sumida K, Shepherd J, Shomaker TS, Buenconsejo-Lum LE, Ueno NT
Cancers, 18, 1441 (2026)
2025
Artificial intelligence-enhanced handheld breast ultrasound for screening: A systematic review of diagnostic test accuracy
Bunnell A, Valdez D, Strand F, Glaser Y, Sadowski P, Shepherd J
PLOS Digital Health, 4, e0001019 (2025)
Prediction of mammographic breast density based on clinical breast ultrasound images using deep learning: a retrospective analysis
Bunnell A, Valdez D, Wolfgruber T, Quon BK, Hung K, Hernandez BY, Seto TB, Killeen J, Miyoshi M, Sadowski P, Shepherd J
The Lancet Regional Health - Americas, 46, 101096 (2025)
2024
Learning a Clinically-Relevant Concept Bottleneck for Lesion Detection in Breast Ultrasound
Bunnell A, Glaser Y, Valdez D, Wolfgruber T, Altamirano A, González CZ, Hernandez BY, Sadowski P, Shepherd J
Lecture notes in computer science, , 650-659 (2024)
The distribution of breast density in women aged 18 years and older
Perera D, Pirikahu S, Walter J, Cadby G, Darcey E, Lloyd R, Hickey M, Saunders C, Hackmann MJ, Sampson DD, Shepherd J, Lilge L, Stone J
Breast Cancer Research and Treatment, 205, 521-531 (2024)
2023
Alternative methods to measure breast density in younger women
Lloyd R, Pirikahu S, Walter J, Cadby G, Darcey E, Perera D, Hickey M, Saunders C, Karnowski K, Sampson DD, Shepherd J, Lilge L, Stone J
British Journal of Cancer, 128, 1701-1709 (2023)
2022
Technical note: Low clinical efficacy, but good acceptability of a point‐of‐care electronic palpation device for breast cancer screening for a lower middle‐income environment
Valdez D, Cruz T, Rania S, Badowski G, Cassel K, Wolfgruber T, Grosskreutz S, Dulana L, Adonay R, Maskarinec G, Shepherd J
Medical Physics, 49, 2663-2671 (2022)
A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women
Kehm RD, Walter EJ, Pereira A, White M, Oskar S, Michels KB, Shepherd J, Lilge L, Terry MB
Scientific Reports, 12, 13547 (2022)
2021
Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk
Rustagi AS, Scott CG, Winham SJ, Brandt KR, Norman AD, Jensen MR, Shepherd J, Hruska CB, Heine J, Pankratz VS, Kerlikowske K, Vachon CM
JNCI Cancer Spectrum, 5, (2021)
Dual-energy three-compartment breast imaging for compositional biomarkers to improve detection of malignant lesions
Leong LT, Malkov S, Drukker K, Niell BL, Sadowski P, Wolfgruber T, Greenwood H, Joe BN, Kerlikowske K, Giger ML, Shepherd J
Communications Medicine, 1, 29 (2021)
The potential of using artificial intelligence to improve skin cancer diagnoses in Hawai‘i’s multiethnic population
Willingham ML, Spencer SY, Lum C, Sanchez JMN, Burnett T, Shepherd J, Cassel K
Melanoma Research, 31, 504-514 (2021)
Deep Learning Predicts Interval and Screening-detected Cancer from Screening Mammograms: A Case-Case-Control Study in 6369 Women
Zhu X, Wolfgruber T, Leong LT, Jensen MR, Scott CG, Winham SJ, Sadowski P, Vachon CM, Kerlikowske K, Shepherd J
Radiology, 301, 550-558 (2021)
Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy
Bodelón C, Mullooly M, Pfeiffer RM, Fan S, Abubakar M, Lenz PH, …, Shepherd J, et al.
Breast Cancer Research, 23, 105 (2021)
2020
Three compartment breast machine learning model for improving computer-aided detection
Leong LT, Giger ML, Drukker K, Kerlikowske K, Joe BN, Greenwood H, Malkov S, Niell BL, Shepherd J
Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy
Hada M, Oh H, Fan S, Falk RT, Geller BM, Vacek PM, …, Shepherd J, et al.
Journal of Clinical Medicine, 9, 245 (2020)
2019
Using Digital Pathology to Understand Epithelial Characteristics of Benign Breast Disease among Women Undergoing Diagnostic Image-Guided Breast Biopsy
Mullooly M, Puvanesarajah S, Fan S, Pfeiffer RM, Olsson LT, Hada M, …, Shepherd J, et al.
Cancer Prevention Research, 12, 861-870 (2019)
Derived mammographic masking measures based on simulated lesions predict the risk of interval cancer after controlling for known risk factors: a case‐case analysis
Hinton B, Ma L, Mahmoudzadeh AP, Malkov S, Fan B, Greenwood H, Joe BN, Lee V, Strand F, Kerlikowske K, Shepherd J
Medical Physics, 46, 1309-1316 (2019)
Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study
Strand F, Azavedo E, Hellgren R, Humphreys K, Eriksson M, Shepherd J, Hall P, Czene K
Breast Cancer Research, 21, 8 (2019)
Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer
Brandt KR, Scott CG, Miglioretti DL, Jensen MR, Mahmoudzadeh AP, Hruska CB, Ma L, Wu F, Cummings SR, Norman AD, Engmann NJ, Shepherd J, Winham SJ, Kerlikowske K, Vachon CM
Breast Cancer Research, 21, 118 (2019)
Deep learning networks find unique mammographic differences in previous negative mammograms between interval and screen-detected cancers: a case-case study
Hinton B, Ma L, Mahmoudzadeh AP, Malkov S, Fan B, Greenwood H, Joe BN, Lee V, Kerlikowske K, Shepherd J
Cancer Imaging, 19, 41 (2019)
Measurement challenge: protocol for international case–control comparison of mammographic measures that predict breast cancer risk
Dench EK, Bond‐Smith D, Darcey E, Lee G, Aung YK, Chan A, …, Shepherd J, et al.
BMJ Open, 9, e031041 (2019)
Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype
Shieh Y, Scott CG, Jensen MR, Norman AD, Bertrand KA, Pankratz VS, Brandt KR, Visscher DW, Shepherd J, Tamimi RM, Vachon CM, Kerlikowske K
Breast Cancer Research, 21, 48 (2019)
2018
Deep learning methods aid in predicting risk of interval cancer
Hinton B, Shepherd J, Kerlikowske K, Joe BN, Greenwood H, Ma L
Combined Benefit of Quantitative Three-Compartment Breast Image Analysis and Mammography Radiomics in the Classification of Breast Masses in a Clinical Data Set
Drukker K, Giger ML, Joe BN, Kerlikowske K, Greenwood H, Drukteinis JS, Niell BL, Fan B, Malkov S, Avila J, Kazemi L, Shepherd J
Radiology, 290, 621-628 (2018)
Automated and Clinical Breast Imaging Reporting and Data System Density Measures Predict Risk for Screen-Detected and Interval Cancers
Kerlikowske K, Scott CG, Mahmoudzadeh AP, Ma L, Winham SJ, Jensen MR, Wu F, Malkov S, Pankratz VS, Cummings SR, Shepherd J, Brandt KR, Miglioretti DL, Vachon CM
Annals of Internal Medicine, 168, 757-765 (2018)
2017
Deep learning and three-compartment breast imaging in breast cancer diagnosis
Drukker K, Huynh BQ, Giger ML, Malkov S, Avila J, Fan B, Joe BN, Kerlikowske K, Drukteinis JS, Kazemi L, Pereira M, Shepherd J
Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE, 10134, 101341F (2017)
Combining quantitative and qualitative breast density measures to assess breast cancer risk
Kerlikowske K, Ma L, Scott CG, Mahmoudzadeh AP, Jensen MR, Sprague BL, Henderson LM, Pankratz VS, Cummings SR, Miglioretti DL, Vachon CM, Shepherd J
Breast Cancer Research, 19, 97 (2017)
2016
Identification, segmentation, and characterization of microcalcifications on mammography
Drukker K, Malkov S, Avila J, Kerlikowske K, Joe BN, Krings G, Creasman JM, Drukteinis JS, Pereira M, Kazemi L, Shepherd J, Giger ML
Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE, 9785, 97850S (2016)
A Measure of Regional Mammographic Masking Based on the CDMAM Phantom
Hinton B, Malkov S, Avila J, Fan B, Joe BN, Kerlikowske K, Ma L, Mahmoudzadeh AP, Shepherd J
Lecture notes in computer science, , 525-531 (2016)
Longitudinal fluctuation in mammographic percent density differentiates between interval and screen‐detected breast cancer
Strand F, Humphreys K, Eriksson M, Li J, Andersson T, Törnberg S, Azavedo E, Shepherd J, Hall P, Czene K
International Journal of Cancer, 140, 34-40 (2016)
Relation of Serum Estrogen Metabolites with Terminal Duct Lobular Unit Involution Among Women Undergoing Diagnostic Image-Guided Breast Biopsy
Oh H, Khodr ZG, Sherman ME, Palakal M, Pfeiffer RM, Linville L, …, Shepherd J, et al.
Hormones and Cancer, 7, 305-315 (2016)
Novel mammographic image features differentiate between interval and screen-detected breast cancer: a case-case study
Strand F, Humphreys K, Cheddad A, Törnberg S, Azavedo E, Shepherd J, Hall P, Czene K
Breast Cancer Research, 18, 100 (2016)
Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis
Felix AS, Lenz PH, Pfeiffer RM, Hewitt SM, Morris J, Patel DA, …, Shepherd J, et al.
Breast Cancer Research, 18, 88 (2016)
Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status
Malkov S, Shepherd J, Scott CG, Tamimi RM, Ma L, Bertrand KA, Couch FJ, Jensen MR, Mahmoudzadeh AP, Fan B, Norman AD, Brandt KR, Pankratz VS, Vachon CM, Kerlikowske K
Breast Cancer Research, 18, 122 (2016)
2015
Dense and Nondense Mammographic Area and Risk of Breast Cancer by Age and Tumor Characteristics
Bertrand KA, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Norman AD, …, Shepherd J, et al.
Cancer Epidemiology Biomarkers & Prevention, 24, 798-809 (2015)
Comparison of Clinical and Automated Breast Density Measurements: Implications for Risk Prediction and Supplemental Screening
Brandt KR, Scott CG, Ma L, Mahmoudzadeh AP, Jensen MR, Whaley DH, Wu F, Malkov S, Hruska CB, Norman AD, Heine J, Shepherd J, Pankratz VS, Kerlikowske K, Vachon CM
Radiology, 279, 710-719 (2015)
2014
Roles of biologic breast tissue composition and quantitative image analysis of mammographic images in breast tumor characterization
Drukker K, Giger ML, Duewer F, Malkov S, Flowers CI, Joe BN, Kerlikowske K, Drukteinis JS, Shepherd J
Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE, 9035, 90351U (2014)
Compositional Three-Component Breast Imaging of Fibroadenoma and Invasive Cancer Lesions: Pilot Study
Malkov S, Duewer F, Kerlikowske K, Drukker K, Giger ML, Shepherd J
Lecture notes in computer science, , 109-114 (2014)
Mammographic quantitative image analysis and biologic image composition for breast lesion characterization and classification
Drukker K, Duewer F, Giger ML, Malkov S, Flowers CI, Joe BN, Kerlikowske K, Drukteinis JS, Li H, Shepherd J
Medical Physics, 41, 031915 (2014)
Automated Measurement of Volumetric Mammographic Density: A Tool for Widespread Breast Cancer Risk Assessment
Brand JS, Czene K, Shepherd J, Leifland K, Heddson B, Sundbom A, Eriksson M, Li J, Humphreys K, Hall P
Cancer Epidemiology Biomarkers & Prevention, 23, 1764-1772 (2014)
Digital mammographic density and breast cancer risk: a case–control study of six alternative density assessment methods
Eng A, Gallant Z, Shepherd J, McCormack V, Li J, Dowsett M, Vinnicombe S, Allen S, dos‐Santos‐Silva I
Breast Cancer Research, 16, 439 (2014)
2013
Mammographic density and risk of breast cancer by age and tumor characteristics
Bertrand KA, Tamimi RM, Scott CG, Jensen MR, Pankratz VS, Visscher DW, …, Shepherd J, et al.
Breast Cancer Research, 15, R104 (2013)
2012
Improvements and Performance of Diagnostic Compositional Imaging Using a Novel Dual-Energy X-ray Technique
Duewer F, Flowers CI, Kerlikowske K, Malkov S, Joe BN, Shepherd J
Lecture notes in computer science, , 569-574 (2012)
2010
Adolescent Diet and Subsequent Serum Hormones, Breast Density, and Bone Mineral Density in Young Women: Results of the Dietary Intervention Study in Children Follow-up Study
Dorgan JF, Liu L, Klifa C, Hylton NM, Shepherd J, Stanczyk FZ, et al.
Cancer Epidemiology Biomarkers & Prevention, 19, 1545-1556 (2010)
2009
Magnetic resonance imaging for secondary assessment of breast density in a high-risk cohort
Klifa C, Carballido‐Gamio J, Wilmes LJ, Laprie A, Shepherd J, Gibbs J, Fan B, Noworolski SM, Hylton NM
Magnetic Resonance Imaging, 28, 8-15 (2009)
Prevention of Breast Cancer in Postmenopausal Women: Approaches to Estimating and Reducing Risk
Cummings SR, Tice JA, Bauer SR, Browner WS, Cuzick J, Ziv E, Vogel V, Shepherd J, Vachon C, Smith‐Bindman R, Kerlikowske K
JNCI Journal of the National Cancer Institute, 101, 384-398 (2009)
2008
Breast Density Assessment in Adolescent Girls Using Dual-Energy X-ray Absorptiometry: A Feasibility Study
Shepherd J, Malkov S, Fan B, Laidevant A, Novotny R, Maskarinec G
Cancer Epidemiology Biomarkers & Prevention, 17, 1709-1713 (2008)
2005
Novel use of Single X-Ray Absorptiometry for Measuring Breast Density
Shepherd J, Hervé L, Landau J, Fan B, Kerlikowske K, Cummings S
Technology in Cancer Research & Treatment, 4, 173-182 (2005)
Are Breast Density and Bone Mineral Density Independent Risk Factors for Breast Cancer?
Kerlikowske K, Shepherd J, Creasman JM, Tice JA, Ziv E, Cummings SR
JNCI Journal of the National Cancer Institute, 97, 368-374 (2005)
Quantification of breast tissue index from MR data using fuzzy clustering
Klifa C, Carballido‐Gamio J, Wilmes LJ, Laprie A, Lobo C, DeMicco E, Watkins MW, Shepherd J, Gibbs J, Hylton NM
2002
Accuracy of mammographic breast density analysis: results of formal operator training.
Prevrhal S, Shepherd J, Smith‐Bindman R, Cummings SR, Kerlikowske K
Cancer Epidemiology, Biomarkers & Prevention, 11, 1389-93 (2002)
Risk Modeling
108 publications · sorted by year, newest first.
2026
Ethnic Mixture and Body Mass Index as Modifiers of Breast Cancer Risk among Native Hawaiian Women: Insights from the Multiethnic Cohort
Valdez D, Abe JV, Bohmann P, Bogumil D, Wilkens LR, Marchand LL, Haiman CA, Shepherd JA, Maskarinec G
Cancer Epidemiology Biomarkers & Prevention, 35, 597-603 (2026)
2025
Visual demonstration of weight loss and health risk improvement with a dual GIP and GLP-1 receptor agonist
Ramirez S, Yang R, Habibovic M, Kennedy S, Bennett JP, Shepherd JA, Thomas DM, Heymsfield SB
International Journal of Obesity, 49, 2005-2010 (2025)
High dietary total energy intake and energy density are associated with girls’ breast density during puberty
Carrasco C, Garmendia ML, Martínez-Arroyo A, Shepherd J, Pereira A
European Journal of Nutrition, 64, 245 (2025)
The gSOS polygenic score is associated with bone density and fracture risk in childhood
Mitchell JA, Bradfield JP, McCormack SE, Chesi A, Kalkwarf HJ, Lappe JM, Oberfield SE, Duren DL, Shepherd J, Hankenson KD, Kelly A, Håkonarson H, Grant SF, Zemel BS
Journal of Bone and Mineral Research, 41, 15-24 (2025)
Prediction of mammographic breast density based on clinical breast ultrasound images using deep learning: a retrospective analysis
Bunnell A, Valdez D, Wolfgruber T, Quon BK, Hung K, Hernandez BY, Seto TB, Killeen J, Miyoshi M, Sadowski P, Shepherd J
The Lancet Regional Health - Americas, 46, 101096 (2025)
2024
Prediction of future visceral adiposity and application to cancer research: The Multiethnic Cohort Study
Wilkens LR, Castelfranco AM, Monroe KR, Kristal BS, Cheng I, Maskarinec G, Hullar MA, Lampe JW, Shepherd J, Franke AA, Ernst T, Marchand LL, Lim U
PLoS ONE, 19, e0306606 (2024)
The Associations between Intakes of One-Carbon Metabolism–Related Vitamins and Breast Density among Young Women
Han E, Horn LV, Snetselaar L, Shepherd J, Park YJ, Kim H, Jung S, Dorgan JF
Cancer Epidemiology Biomarkers & Prevention, 33, 567-575 (2024)
The Prospective Association between Early Life Growth and Breast Density in Young Adult Women
Lloyd R, Pirikahu S, Walter EJ, Cadby G, Warrington NM, Perera D, Hickey M, Saunders C, Hackmann MJ, Sampson DD, Shepherd J, Lilge L, Stone J
Cancers, 16, 2418 (2024)
Time‐specific impact of trace metals on breast density of adolescent girls in Santiago, Chile
Kim CE, Pereira A, Binder AM, Amarasiriwardena C, Shepherd J, Corvalán C, Michels KB
International Journal of Cancer, 155, 627-636 (2024)
The DIRAC framework: Geometric structure underlies roles of and in combining classifiers
Sniatynski MJ, Shepherd J, Wilkens LR, Hsu DF, Kristal BS
Patterns, 5, 100924 (2024)
Breast composition during and after puberty: the Chilean Growth and Obesity Cohort Study
Pereira A, Garmendia ML, Leiva V, Corvalán C, Michels KB, Shepherd J
Breast Cancer Research, 26, 45 (2024)
The distribution of breast density in women aged 18 years and older
Perera D, Pirikahu S, Walter J, Cadby G, Darcey E, Lloyd R, Hickey M, Saunders C, Hackmann MJ, Sampson DD, Shepherd J, Lilge L, Stone J
Breast Cancer Research and Treatment, 205, 521-531 (2024)
2023
Untargeted serum metabolomic profiles and breast density in young women
Jung S, Silva S, Dallal CM, LeBlanc ES, Paris K, Shepherd J, Snetselaar L, Horn LV, Zhang Y, Dorgan JF
Cancer Causes & Control, 35, 323-334 (2023)
Time-specific impact of mono-benzyl phthalate (MBzP) and perfluorooctanoic acid (PFOA) on breast density of a Chilean adolescent Cohort
Kim CE, Binder AM, Corvalán C, Pereira A, Shepherd J, Calafat AM, Botelho JC, Hampton JM, Trentham‐Dietz A, Michels KB
Environment International, 181, 108241 (2023)
2022
Habitual Phytoestrogen Intake Is Associated with Breast Composition in Girls at 2 Years after Menarche Onset
Lesser C, Mericq V, Reyes M, Garmendia ML, Shepherd JA, Michels KB, Corvalán C, Pereira A
Cancer Epidemiology Biomarkers & Prevention, 31, 1334-1340 (2022)
Prognostic utility of self‐reported sarcopenia (SARC‐F) in the Multiethnic Cohort
Wu AH, Setiawan VW, Lim U, Tseng C, White KK, Shepherd J, Lenz HJ, Cheng I, Stram DO, Haiman CA, Wilkens LR, Marchand LL
Journal of Cachexia Sarcopenia and Muscle, 13, 987-1002 (2022)
Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls
Yoon L, Binder AM, Pereira A, Calafat AM, Shepherd J, Corvalán C, Michels KB
Environment International, 170, 107586 (2022)
Deep learning predicts all-cause mortality from longitudinal total-body DXA imaging
Glaser Y, Shepherd J, Leong LT, Wolfgruber T, Lui L, Sadowski P, Cummings SR
Communications Medicine, 2, 102 (2022)
A comparison of various methods for measuring breast density and breast tissue composition in adolescent girls and women
Kehm RD, Walter EJ, Pereira A, White M, Oskar S, Michels KB, Shepherd J, Lilge L, Terry MB
Scientific Reports, 12, 13547 (2022)
Three‐dimensional optical body shape and features improve prediction of metabolic disease risk in a diverse sample of adults
Bennett JP, Liu YE, Quon BK, Kelly NN, Leong LT, Wong MC, Kennedy S, Chow DC, Garber AK, Weiss EJ, Heymsfield SB, Shepherd J
Obesity, 30, 1589-1598 (2022)
2021
Biomarker-based visceral adiposity score and incident type 2 diabetes in the multiethnic cohort
Maskarinec G, Raquinio PA, Setiawan VW, Ernst T, Franke AA, Buchthal SD, Shepherd J, Wilkens LR, Lim U, Marchand LL
Annals of Epidemiology, 63, 29-34 (2021)
Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk
Rustagi AS, Scott CG, Winham SJ, Brandt KR, Norman AD, Jensen MR, Shepherd J, Hruska CB, Heine J, Pankratz VS, Kerlikowske K, Vachon CM
JNCI Cancer Spectrum, 5, (2021)
Ranks underlie outcome of combining classifiers: Quantitative roles for and
Sniatynski MJ, Shepherd J, Ernst T, Wilkens LR, Hsu DF, Kristal BS
Patterns, 3, 100415 (2021)
Dual-energy three-compartment breast imaging for compositional biomarkers to improve detection of malignant lesions
Leong LT, Malkov S, Drukker K, Niell BL, Sadowski P, Wolfgruber T, Greenwood H, Joe BN, Kerlikowske K, Giger ML, Shepherd J
Communications Medicine, 1, 29 (2021)
The potential of using artificial intelligence to improve skin cancer diagnoses in Hawai‘i’s multiethnic population
Willingham ML, Spencer SY, Lum C, Sanchez JMN, Burnett T, Shepherd J, Cassel K
Melanoma Research, 31, 504-514 (2021)
Mammographic Variation Measures, Breast Density, and Breast Cancer Risk
Heine J, Fowler E, Scott CG, Jensen MR, Shepherd J, Hruska CB, Winham SJ, Brandt KR, Wu F, Norman AD, Pankratz VS, Miglioretti DL, Kerlikowske K, Vachon CM
American Journal of Roentgenology, 217, 326-335 (2021)
Association of mammographic density measures and breast cancer “intrinsic” molecular subtypes
Kleinstern G, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Bertrand KA, …, Shepherd J, et al.
Breast Cancer Research and Treatment, 187, 215-224 (2021)
The Gut Microbiome Is Associated with Circulating Dietary Biomarkers of Fruit and Vegetable Intake in a Multiethnic Cohort
Frankenfeld CL, Hullar MA, Maskarinec G, Monroe KR, Shepherd J, Franke AA, Randolph TW, Wilkens LR, Boushey CJ, Marchand LL, Lim U, Lampe JW
Journal of the Academy of Nutrition and Dietetics, 122, 78-98 (2021)
Deep Learning Predicts Interval and Screening-detected Cancer from Screening Mammograms: A Case-Case-Control Study in 6369 Women
Zhu X, Wolfgruber T, Leong LT, Jensen MR, Scott CG, Winham SJ, Sadowski P, Vachon CM, Kerlikowske K, Shepherd J
Radiology, 301, 550-558 (2021)
Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy
Bodelón C, Mullooly M, Pfeiffer RM, Fan S, Abubakar M, Lenz PH, …, Shepherd J, et al.
Breast Cancer Research, 23, 105 (2021)
2020
Effect of excessive gestational weight on daughters’ breast density at the end of puberty onset
López A, Garmendia ML, Shepherd J, Michels KB, Corvalán C, Pereira A
Scientific Reports, 10, 6636 (2020)
Three compartment breast machine learning model for improving computer-aided detection
Leong LT, Giger ML, Drukker K, Kerlikowske K, Joe BN, Greenwood H, Malkov S, Niell BL, Shepherd J
Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy
Hada M, Oh H, Fan S, Falk RT, Geller BM, Vacek PM, …, Shepherd J, et al.
Journal of Clinical Medicine, 9, 245 (2020)
Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche
Michels KB, Keller K, Pereira A, Kim CE, Santos JL, Shepherd J, Corvalán C, Binder AM
Breast Cancer Research, 22, 104 (2020)
Distinct phenotypic characteristics of normal-weight adults at risk of developing cardiovascular and metabolic diseases
Stanley A, Schuna JM, Yang S, Kennedy S, Heo M, Wong MC, Shepherd J, Heymsfield SB
American Journal of Clinical Nutrition, 112, 967-978 (2020)
Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217
Northey JJ, Barrett A, Acerbi I, Hayward M, Talamantes S, Dean I, …, Shepherd J, et al.
Journal of Clinical Investigation, 130, 5721-5737 (2020)
2019
Using Digital Pathology to Understand Epithelial Characteristics of Benign Breast Disease among Women Undergoing Diagnostic Image-Guided Breast Biopsy
Mullooly M, Puvanesarajah S, Fan S, Pfeiffer RM, Olsson LT, Hada M, …, Shepherd J, et al.
Cancer Prevention Research, 12, 861-870 (2019)
Derived mammographic masking measures based on simulated lesions predict the risk of interval cancer after controlling for known risk factors: a case‐case analysis
Hinton B, Ma L, Mahmoudzadeh AP, Malkov S, Fan B, Greenwood H, Joe BN, Lee V, Strand F, Kerlikowske K, Shepherd J
Medical Physics, 46, 1309-1316 (2019)
Association of Imaging-Based Body Fat Distribution and Mammographic Density in the Multiethnic Cohort Adiposity Phenotype Study
Maskarinec G, Ciba M, Ju D, Shepherd J, Ernst T, Wu AH, Monroe KR, Lim U, Wilkens LR, Marchand LL
Cancer Epidemiology Biomarkers & Prevention, 29, 352-358 (2019)
Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy
Hada M, Oh H, Pfeiffer RM, Falk RT, Fan S, Mullooly M, …, Shepherd J, et al.
Breast Cancer Research, 21, 81 (2019)
Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study
Strand F, Azavedo E, Hellgren R, Humphreys K, Eriksson M, Shepherd J, Hall P, Czene K
Breast Cancer Research, 21, 8 (2019)
Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer
Brandt KR, Scott CG, Miglioretti DL, Jensen MR, Mahmoudzadeh AP, Hruska CB, Ma L, Wu F, Cummings SR, Norman AD, Engmann NJ, Shepherd J, Winham SJ, Kerlikowske K, Vachon CM
Breast Cancer Research, 21, 118 (2019)
Deep learning networks find unique mammographic differences in previous negative mammograms between interval and screen-detected cancers: a case-case study
Hinton B, Ma L, Mahmoudzadeh AP, Malkov S, Fan B, Greenwood H, Joe BN, Lee V, Kerlikowske K, Shepherd J
Cancer Imaging, 19, 41 (2019)
Measurement challenge: protocol for international case–control comparison of mammographic measures that predict breast cancer risk
Dench EK, Bond‐Smith D, Darcey E, Lee G, Aung YK, Chan A, …, Shepherd J, et al.
BMJ Open, 9, e031041 (2019)
Application of convolutional neural networks to breast biopsies to delineate tissue correlates of mammographic breast density
Mullooly M, Bejnordi BE, Pfeiffer RM, Fan S, Palakal M, Hada M, …, Shepherd J, et al.
npj Breast Cancer, 5, 43 (2019)
Longitudinal Changes in Volumetric Breast Density in Healthy Women across the Menopausal Transition
Engmann NJ, Scott CG, Jensen MR, Winham SJ, Ma L, Brandt KR, …, Shepherd J, et al.
Cancer Epidemiology Biomarkers & Prevention, 28, 1324-1330 (2019)
Combined effect of volumetric breast density and body mass index on breast cancer risk
Engmann NJ, Scott CG, Jensen MR, Winham SJ, Miglioretti DL, Ma L, …, Shepherd J, et al.
Breast Cancer Research and Treatment, 177, 165-173 (2019)
Pubertal timing and breast density in young women: a prospective cohort study
Houghton LC, Jung S, Troisi R, LeBlanc ES, Snetselaar L, Hylton NM, Klifa C, Horn LV, Paris K, Shepherd J, Hoover RN, Dorgan JF
Breast Cancer Research, 21, 122 (2019)
Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype
Shieh Y, Scott CG, Jensen MR, Norman AD, Bertrand KA, Pankratz VS, Brandt KR, Visscher DW, Shepherd J, Tamimi RM, Vachon CM, Kerlikowske K
Breast Cancer Research, 21, 48 (2019)
2018
Deep learning methods aid in predicting risk of interval cancer
Hinton B, Shepherd J, Kerlikowske K, Joe BN, Greenwood H, Ma L
Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls
Binder AM, Stiemsma LT, Keller K, Otterdijk SDV, Mericq V, Pereira A, Santos JL, Shepherd J, Michels KB
Clinical Epigenetics, 10, 122 (2018)
Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women
Jung S, Goloubeva O, Hylton NM, Klifa C, LeBlanc ES, Shepherd J, Snetselaar L, Horn LV, Dorgan JF
Cancer Causes & Control, 29, 631-642 (2018)
Does mammographic density mediate risk factor associations with breast cancer? An analysis by tumor characteristics
Rice MS, Tamimi RM, Bertrand KA, Scott CG, Jensen MR, Norman AD, …, Shepherd J, et al.
Breast Cancer Research and Treatment, 170, 129-141 (2018)
Combined Benefit of Quantitative Three-Compartment Breast Image Analysis and Mammography Radiomics in the Classification of Breast Masses in a Clinical Data Set
Drukker K, Giger ML, Joe BN, Kerlikowske K, Greenwood H, Drukteinis JS, Niell BL, Fan B, Malkov S, Avila J, Kazemi L, Shepherd J
Radiology, 290, 621-628 (2018)
Prepubertal and Pubertal Endocrine-Disrupting Chemical Exposure and Breast Density among Chilean Adolescents
Binder AM, Corvalán C, Pereira A, Calafat AM, Ye X, Shepherd J, Michels KB
Cancer Epidemiology Biomarkers & Prevention, 27, 1491-1499 (2018)
Automated and Clinical Breast Imaging Reporting and Data System Density Measures Predict Risk for Screen-Detected and Interval Cancers
Kerlikowske K, Scott CG, Mahmoudzadeh AP, Ma L, Winham SJ, Jensen MR, Wu F, Malkov S, Pankratz VS, Cummings SR, Shepherd J, Brandt KR, Miglioretti DL, Vachon CM
Annals of Internal Medicine, 168, 757-765 (2018)
2017
Interaction of mammographic breast density with menopausal status and postmenopausal hormone use in relation to the risk of aggressive breast cancer subtypes
Yaghjyan L, Tamimi RM, Bertrand KA, Scott CG, Jensen MR, Pankratz VS, …, Shepherd J, et al.
Breast Cancer Research and Treatment, 165, 421-431 (2017)
Determinants of volumetric breast density in Chilean premenopausal women
Pereira A, Garmendia ML, Uauy R, Neira P, López‐Arana S, Malkov S, Shepherd J
Breast Cancer Research and Treatment, 162, 343-352 (2017)
FRAX-based Estimates of 10-year Probability of Hip and Major Osteoporotic Fracture Among Adults Aged 40 and Over: United States, 2013 and 2014.
Looker AC, Isfahani NS, Fan B, Shepherd J
National Health Statistics Reports, , 1-16 (2017)
Combining quantitative and qualitative breast density measures to assess breast cancer risk
Kerlikowske K, Ma L, Scott CG, Mahmoudzadeh AP, Jensen MR, Sprague BL, Henderson LM, Pankratz VS, Cummings SR, Miglioretti DL, Vachon CM, Shepherd J
Breast Cancer Research, 19, 97 (2017)
Longitudinal Changes in Volumetric Breast Density with Tamoxifen and Aromatase Inhibitors
Engmann NJ, Scott CG, Jensen MR, Ma L, Brandt KR, Mahmoudzadeh AP, …, Shepherd J, et al.
Cancer Epidemiology Biomarkers & Prevention, 26, 930-937 (2017)
Faster ticking rate of the epigenetic clock is associated with faster pubertal development in girls
Binder AM, Corvalán C, Mericq V, Pereira A, Santos JL, Horvath S, Shepherd J, Michels KB
Epigenetics, 13, 85-94 (2017)
2016
Do Women with Low Breast Density Have Regionally High Breast Density?
Mahmoudzadeh AP, Malkov S, Hinton B, Sprague BL, Kerlikowske K, Shepherd J
Lecture notes in computer science, , 548-553 (2016)
Longitudinal fluctuation in mammographic percent density differentiates between interval and screen‐detected breast cancer
Strand F, Humphreys K, Eriksson M, Li J, Andersson T, Törnberg S, Azavedo E, Shepherd J, Hall P, Czene K
International Journal of Cancer, 140, 34-40 (2016)
Relation of Serum Estrogen Metabolites with Terminal Duct Lobular Unit Involution Among Women Undergoing Diagnostic Image-Guided Breast Biopsy
Oh H, Khodr ZG, Sherman ME, Palakal M, Pfeiffer RM, Linville L, …, Shepherd J, et al.
Hormones and Cancer, 7, 305-315 (2016)
Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and terminal duct lobular unit involution of the breast: a cross-sectional study of women with benign breast disease
Horne HN, Sherman ME, Pfeiffer RM, Figueroa JD, Khodr ZG, Falk RT, …, Shepherd J, et al.
Breast Cancer Research, 18, 24 (2016)
Novel mammographic image features differentiate between interval and screen-detected breast cancer: a case-case study
Strand F, Humphreys K, Cheddad A, Törnberg S, Azavedo E, Shepherd J, Hall P, Czene K
Breast Cancer Research, 18, 100 (2016)
Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis
Felix AS, Lenz PH, Pfeiffer RM, Hewitt SM, Morris J, Patel DA, …, Shepherd J, et al.
Breast Cancer Research, 18, 88 (2016)
Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status
Malkov S, Shepherd J, Scott CG, Tamimi RM, Ma L, Bertrand KA, Couch FJ, Jensen MR, Mahmoudzadeh AP, Fan B, Norman AD, Brandt KR, Pankratz VS, Vachon CM, Kerlikowske K
Breast Cancer Research, 18, 122 (2016)
2015
Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy
Bodelón C, Heaphy CM, Meeker AK, Geller BM, Vacek PM, Weaver DL, Chicoine RE, Shepherd J, Mahmoudzadeh AP, Patel D, Brinton LA, Sherman ME, Gierach GL
BMC Cancer, 15, 823 (2015)
Relationship of Serum Estrogens and Metabolites with Area and Volume Mammographic Densities
Gierach GL, Patel DA, Falk RT, Pfeiffer RM, Geller BM, Vacek PM, …, Shepherd J, et al.
Hormones and Cancer, 6, 107-119 (2015)
Adolescent endogenous sex hormones and breast density in early adulthood
Jung S, Egleston BL, Chandler DW, Horn LV, Hylton NM, Klifa CC, Lasser NL, LeBlanc ES, Paris K, Shepherd J, Snetselaar L, Stanczyk FZ, Stevens VJ, Dorgan JF
Breast Cancer Research, 17, 77 (2015)
Genetic Risk Scores Implicated in Adult Bone Fragility Associate With Pediatric Bone Density
Mitchell JA, Chesi A, Elci OU, McCormack SE, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd J, Kelly A, Grant SF, Zemel BS
Journal of Bone and Mineral Research, 31, 789-795 (2015)
The Effect of Change in Body Mass Index on Volumetric Measures of Mammographic Density
Hart V, Reeves KW, Sturgeon SR, Reich NG, Sievert LL, Kerlikowske K, Ma L, Shepherd J, Tice JA, Mahmoudzadeh AP, Malkov S, Sprague BL
Cancer Epidemiology Biomarkers & Prevention, 24, 1724-1730 (2015)
Sex and Ethnic Differences in the Association of Obesity With Risk of Hepatocellular Carcinoma
Setiawan VW, Lim U, Lipworth L, Lu SC, Shepherd J, Ernst T, Wilkens LR, Henderson BE, Marchand LL
Clinical Gastroenterology and Hepatology, 14, 309-316 (2015)
Body fatness during childhood and adolescence and breast density in young women: a prospective analysis
Bertrand KA, Baer HJ, Orav EJ, Klifa C, Shepherd J, Horn LV, Snetselaar L, Stevens VJ, Hylton NM, Dorgan JF
Breast Cancer Research, 17, 95 (2015)
Dense and Nondense Mammographic Area and Risk of Breast Cancer by Age and Tumor Characteristics
Bertrand KA, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Norman AD, …, Shepherd J, et al.
Cancer Epidemiology Biomarkers & Prevention, 24, 798-809 (2015)
Relationship of Terminal Duct Lobular Unit Involution of the Breast with Area and Volume Mammographic Densities
Gierach GL, Patel DA, Pfeiffer RM, Figueroa JD, Linville L, Papathomas D, …, Shepherd J, et al.
Cancer Prevention Research, 9, 149-158 (2015)
Fracture Risk Prediction by Non-BMD DXA Measures: the 2015 ISCD Official Positions Part 1: Hip Geometry
Broy SB, Cauley JA, Lewiecki M, Schousboe JT, Shepherd J, Leslie WD
Journal of Clinical Densitometry, 18, 287-308 (2015)
Comparison of Clinical and Automated Breast Density Measurements: Implications for Risk Prediction and Supplemental Screening
Brandt KR, Scott CG, Ma L, Mahmoudzadeh AP, Jensen MR, Whaley DH, Wu F, Malkov S, Hruska CB, Norman AD, Heine J, Shepherd J, Pankratz VS, Kerlikowske K, Vachon CM
Radiology, 279, 710-719 (2015)
Executive Summary of the 2015 ISCD Position Development Conference on Advanced Measures From DXA and QCT: Fracture Prediction Beyond BMD
Shepherd J, Schousboe JT, Broy SB, Engelke K, Leslie WD
Journal of Clinical Densitometry, 18, 274-286 (2015)
Fracture Risk Prediction by Non-BMD DXA Measures: the 2015 ISCD Official Positions Part 2: Trabecular Bone Score
Silva BC, Broy SB, Boutroy S, Schousboe JT, Shepherd J, Leslie WD
Journal of Clinical Densitometry, 18, 309-330 (2015)
2014
Roles of biologic breast tissue composition and quantitative image analysis of mammographic images in breast tumor characterization
Drukker K, Giger ML, Duewer F, Malkov S, Flowers CI, Joe BN, Kerlikowske K, Drukteinis JS, Shepherd J
Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE, 9035, 90351U (2014)
Automated Volumetric Breast Density Derived by Statistical Model Approach
Malkov S, Mahmoudzadeh AP, Kerlikowske K, Shepherd J
Lecture notes in computer science, , 257-264 (2014)
Enhancement of Mammographic Density Measures in Breast Cancer Risk Prediction
Cheddad A, Czene K, Shepherd J, Li J, Hall P, Humphreys K
Cancer Epidemiology Biomarkers & Prevention, 23, 1314-1323 (2014)
Endogenous Sex Hormones and Breast Density in Young Women
Jung S, Stanczyk FZ, Egleston BL, Snetselaar L, Stevens VJ, Shepherd J, Horn LV, LeBlanc ES, Paris K, Klifa C, Dorgan JF
Cancer Epidemiology Biomarkers & Prevention, 24, 369-378 (2014)
Dietary Energy Density Is Positively Associated with Breast Density among Young Women
Jones JA, Hartman TJ, Klifa C, Coffman DL, Mitchell DC, Vernarelli JA, Snetselaar L, Horn LV, Stevens VJ, Robson AM, Himes JH, Shepherd J, Dorgan JF
Journal of the Academy of Nutrition and Dietetics, 115, 353-359 (2014)
First pregnancy events and future breast density: modification by age at first pregnancy and specific VEGF and IGF1R gene variants
Prebil LA, Ereman R, Powell M, Jamshidian F, Kerlikowske K, Shepherd J, Hurlbert M, Benz CC
Cancer Causes & Control, 25, 859-868 (2014)
Comparison of Mammographic Density Assessed as Volumes and Areas among Women Undergoing Diagnostic Image-Guided Breast Biopsy
Gierach GL, Geller BM, Shepherd J, Patel DA, Vacek PM, Weaver DL, Chicoine RE, Pfeiffer RM, Fan B, Mahmoudzadeh AP, Wang J, Johnson JM, Herschorn SD, Brinton LA, Sherman ME
Cancer Epidemiology Biomarkers & Prevention, 23, 2338-2348 (2014)
Automated Measurement of Volumetric Mammographic Density: A Tool for Widespread Breast Cancer Risk Assessment
Brand JS, Czene K, Shepherd J, Leifland K, Heddson B, Sundbom A, Eriksson M, Li J, Humphreys K, Hall P
Cancer Epidemiology Biomarkers & Prevention, 23, 1764-1772 (2014)
Digital mammographic density and breast cancer risk: a case–control study of six alternative density assessment methods
Eng A, Gallant Z, Shepherd J, McCormack V, Li J, Dowsett M, Vinnicombe S, Allen S, dos‐Santos‐Silva I
Breast Cancer Research, 16, 439 (2014)
2013
High mammographic density in women of Ashkenazi Jewish descent
Caswell‐Jin JL, Kerlikowske K, Shepherd J, Cummings SR, Hu D, Huntsman S, Ziv E
Breast Cancer Research, 15, R40 (2013)
Menstrual and reproductive characteristics and breast density in young women
Dorgan JF, Klifa C, Deshmukh S, Egleston BL, Shepherd J, Kwiterovich PO, Horn LV, Snetselaar L, Stevens VJ, Robson AM, Lasser NL, Hylton NM
Cancer Causes & Control, 24, 1973-1983 (2013)
Agreement of Mammographic Measures of Volumetric Breast Density to MRI
Wang J, Azziz A, Fan B, Malkov S, Klifa C, Newitt DC, Yitta S, Hylton NM, Kerlikowske K, Shepherd J
PLoS ONE, 8, e81653 (2013)
Mammographic density and risk of breast cancer by age and tumor characteristics
Bertrand KA, Tamimi RM, Scott CG, Jensen MR, Pankratz VS, Visscher DW, …, Shepherd J, et al.
Breast Cancer Research, 15, R104 (2013)
2012
Do fatty breasts increase or decrease breast cancer risk?
Shepherd J, Kerlikowske K
Breast Cancer Research, 14, 102 (2012)
2011
A comparison of breast density measures between mothers and adolescent daughters
Maskarinec G, Morimoto Y, Daida YG, Shepherd J, Novotny R
BMC Cancer, 11, 330 (2011)
Volume of Mammographic Density and Risk of Breast Cancer
Shepherd J, Kerlikowske K, Ma L, Duewer F, Fan B, Wang J, Malkov S, Vittinghoff E, Cummings SR
Cancer Epidemiology Biomarkers & Prevention, 20, 1473-1482 (2011)
2010
Comparison of Subregional Breast Density with Whole Breast Density
Malkov S, Ma L, Kerlikowske K, Wang J, Cummings S, Shepherd J
Lecture notes in computer science, , 402-407 (2010)
Adolescent Diet and Subsequent Serum Hormones, Breast Density, and Bone Mineral Density in Young Women: Results of the Dietary Intervention Study in Children Follow-up Study
Dorgan JF, Liu L, Klifa C, Hylton NM, Shepherd J, Stanczyk FZ, et al.
Cancer Epidemiology Biomarkers & Prevention, 19, 1545-1556 (2010)
2009
Magnetic resonance imaging for secondary assessment of breast density in a high-risk cohort
Klifa C, Carballido‐Gamio J, Wilmes LJ, Laprie A, Shepherd J, Gibbs J, Fan B, Noworolski SM, Hylton NM
Magnetic Resonance Imaging, 28, 8-15 (2009)
Prevention of Breast Cancer in Postmenopausal Women: Approaches to Estimating and Reducing Risk
Cummings SR, Tice JA, Bauer SR, Browner WS, Cuzick J, Ziv E, Vogel V, Shepherd J, Vachon C, Smith‐Bindman R, Kerlikowske K
JNCI Journal of the National Cancer Institute, 101, 384-398 (2009)
2008
Breast Density Assessment in Adolescent Girls Using Dual-Energy X-ray Absorptiometry: A Feasibility Study
Shepherd J, Malkov S, Fan B, Laidevant A, Novotny R, Maskarinec G
Cancer Epidemiology Biomarkers & Prevention, 17, 1709-1713 (2008)
2005
Novel use of Single X-Ray Absorptiometry for Measuring Breast Density
Shepherd J, Hervé L, Landau J, Fan B, Kerlikowske K, Cummings S
Technology in Cancer Research & Treatment, 4, 173-182 (2005)
Are Breast Density and Bone Mineral Density Independent Risk Factors for Breast Cancer?
Kerlikowske K, Shepherd J, Creasman JM, Tice JA, Ziv E, Cummings SR
JNCI Journal of the National Cancer Institute, 97, 368-374 (2005)
Quantification of breast tissue index from MR data using fuzzy clustering
Klifa C, Carballido‐Gamio J, Wilmes LJ, Laprie A, Lobo C, DeMicco E, Watkins MW, Shepherd J, Gibbs J, Hylton NM
2004
Mammographic Density and Estrogen Receptor Status of Breast Cancer
Ziv E, Tice JA, Smith‐Bindman R, Shepherd J, Cummings SR, Kerlikowske K
Cancer Epidemiology Biomarkers & Prevention, 13, 2090-2095 (2004)
2002
Accuracy of mammographic breast density analysis: results of formal operator training.
Prevrhal S, Shepherd J, Smith‐Bindman R, Cummings SR, Kerlikowske K
Cancer Epidemiology, Biomarkers & Prevention, 11, 1389-93 (2002)